Effect of pentacyn and tetoxacyn on acceleration of plutonium elimination from human organism

"Radiation and Risk", 1995, vol. 5, pp. 68-73


Plotnikova L.A., Baisogolov G.D., Doschenko V.N.


In order to accelerate an elimination of Pu-239 from organism the 19 workers involved into plutonium production were treated by pentacyn and tetoxacyn. Intravenous injection of pentacyn (8-24 ml as a 10% solution) and tetoxacyn (10 ml as a 10% solution) was demonstrated to accelerate elimination of plutonium from human organism largely with urine. Pentacyn was a more effective and a less toxic preparation compared to tetoxacyn.

Key words
239Pu, pentacin, tetoxacin, plutonium removal acceleration, human organism.


1. Belyaev, Yu.A. Effect of diaminocyclohexate tetraacetic acid salt on plutonium exchange in rats. Collection of essays on radiation medicine for 1957, vol. 2. M., Medgiz, 1959, p. 22.

2. Foreman H., Moss W., Eustler B. Clinical experiences with radioactive materials. Am. J. Roentgenol., 1958, 79, 6, 1071.

3. Razumovsky N.O., Torchinskaya OL, Balabukha V.S. Reducing deposits in the body of yttrium-91 and cerium-144 with the help of some complexing agents. Biophysics, 1961, 5, 610.

4. Catsch A., Le D.Kh., Melchinger H. Die Wirkung von Diaminodiothylthertetraessigsaure und Dieatylentriaminpentaessigsaure auf die Verteilung von Radiocer, Strahlentherapie, 1958, 106, 606.

5. Catsch A., Le D.Kh. Removal of internally deposited radiocerium by the use of chalating agents. Nature, 1957, 180, 4586, 609.

6. Belyaev, Yu.A. Possible ways of influencing the excretion of plutonium from animals. In the book. "The biological effects of radiation and the distribution of radioactive isotopes." Gosatomizdat, 1961, p. 182.

7. Smith V.N. Removal of internally deposited plutonium. Nature, 1958, 181, 4626, 1792.

8. Schubert J., Fried J.F., Rosenthal M.W., Lin denbaum A. Tissue distribution of monomeric and polimeric plutonium as modified by a chelating agent. Rad. Res., 1961, 15, 2, 220.

9. Smith H.V., John E.B., William J.Cl., Ray C.F. Effectiveness of DTPA in removing plutonium from the pig. Proc. Soc. exp. Biol. (N. Y.), 1961, 107, 1, 120.

10. Popov S.I. A practical guide to the quantitative determination of radioactive substances in biosubstrates. M., 1957.

Full text article (in Russian)