Comparative analysis of antitumor efficiency of photodynamic therapy with amidoaminchlorine and liposomal form of amidoaminchlorine in experimental tumor M-1

«Radiation and Risk», 2015, vol. 24, No. 1, pp.85-95

Authors

Malygina A.I. ¹ – Senior Researcher, C. Sc., Biol., Tsyb MRRC, Obninsk.
Mihaylovskaya A.A.¹ – Head of Lab., C. Sc., Biol., A. Tsyb MRRC, Obninsk. Contacts: 4 Korolyov str., Obninsk, Kaluga Region, Russia, 249036. Tel. (484) 399-30-26; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Drozhzhina V.V.¹ – Researcher Assistant, A. Tsyb MRRC, Obninsk.
Arhipova L.M.¹ – Researcher, A. Tsyb MRRC, Obninsk.
Osipchuk J.S.¹ – Researcher Assistant, A. Tsyb MRRC, Obninsk.
Ponomarev H.V.² – Chief Researcher, D.Sc., Chem., Prof., Institute of Biomedical Chemistry, Moscow

Abstract

The purpose of the study was to compare antitumor efficiency of photodynamic therapy with amidoaminchlorine and its liposomal form. The research was carried out with the use of experimental model sarcoma M-1 implanted in white female rats. One group of rats received amidoaminchlorine, the second group received liposomal form of the photosensitizer, parameters of laser radiation were identical. In 3.5 hours following intraperitoneal administration of amidoaminchlorine or its liposomal form the tumor was irradiated by laser. Antitumor efficiency of the treatment was evaluated on the 21 day by the index of absolute tumor growth inhibition. For data analysis statistical software “Statistica” was used. Analysis showed that amidoaminochlorine and its liposomal form are effective photosensitizers, however, the latter was more effective.

Key words
Sarcoma M-1, photosensitizer, lazer, statistical analysis, amidoaminchlorine, liposomal form of amidoaminchlorine, complete tumor regression, antitumor efficiency, kinetics, laser power density.

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