Issues
Comparative analysis of thyropathy incidence rate in children of the Kaluga oblast exposed to iodine-131 at different time of their life from conception to 7 years old
«Radiation and Risk», 2015, vol. 24, No. 1, pp.74-84
Authors
Gorobets V.F. – Lead. Researcher, C. Sc., Med. A. Tsyb MRRC, Obninsk. Contacts: 4 Korolyov str., Obninsk, Kaluga Region, Russia, 249036. Tel. (484) 399-30-11; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
The highest radioactive fallout in the Kaluga oblast contained iodine-131 following the Chernobyl accident was registered in south-west Zhizdra, Ulianovsky and Khvastovichi rayons, characterized by moderate iodine deficiency. Radioiodine in measurable quantities was detected there from 29 April to 28 July 1986. The purpose of the study is to compare incidence rate of thyroid disorders registered during 12 years after July 1986 in permanent residents of the rayons, exposed to radiation at different time of their life – from conception to 7 years old and in unexposed children of the same age. The cohort study was carried out. The incidence rate was higher in those who was exposed to radioiodine-131 in increased age regardless simultaneous decrease of absorbed dose to the thyroid. Thyropathy incidence rate in children unexposed to radioiodine was 2.5-3.4 times lower, however, it was detected more frequently in people of increased age. This increase is caused by iodine deficiency. Conclusions. In children exposed to radioidine at different time of their life – from conception to 7 years old – increased incidence of thyroid diseases was caused by synergistic action of radioiodine and iodine deficiency.
Key words
Chernobyl accident, Kaluga region, children, iodine deficiency, technogenic iodine-131, irradiation of thyroid, age from conception till seven years, cohort study, thyroid diseases, incidence rate, comparative analysis.
References
1. Clinical Endocrinology. Guide for physicians. Ed.: Kholodova Ye.A. Moscow, Medical Information Agency Ltd., 2011. 736 p. (In Russian).
2. Hetzel B.S. The iodine deficiency disorders. Iodine deficiency in Europe: a continuing concern. Ed.: Delange F., Dunn J.T., Glinoer D. New York, Plenum Press, 1993, pp. 25-31.
3. Kasatkina E.P. The iodine deficiency disorders at children and adolescents (plenary lecture). Problemy endocrinologii – Problems of Endocrinology, 1997, vol. 43, no. 3, pp. 3-7. (In Russian).
4. Gerasimov G.A., Fadeev V.V., Sviridenko N.Yu., Melnichenko G.A., Dedov I.I. The iodine deficiency disorders in Russia. The simple solution of complicated problem. Moscow, Adamant Publ., 2002. 168 p. (In Russian).
5. Contamination of Russian territories with radionuclides 137Cs, 90Sr, 239Pu+240Pu, 131I. Radiatsiya i risk – Radiation and Risk, 1993, issue 3, supplement 1, pp. 3-153. (In Russian).
6. Gorobets V.F. The dependence of incidence rates of non-cancer thyroid diseases in the postnatal period at the Kaluga region children from term gestation, on which has taken place them in utero irradiation owing to technogenic iodine-131 incorporation. Radiatsiya i risk – Radiation and Risk, 2011, vol. 20, no. 1, pp. 24-33. (In Russian).
7. Drjevetskaya I.A. The endocrine system of growing organism. Moscow, Higher School Publ., 1987. 207 p. (In Russian).
8. Mazurin A.V., Vorontsov I.M. Introduction to children's illnesses. Moscow, Medicine, 1985. 432 p. (In Russian).
9. Ahlbom A., Norell S. Introduction to modern epidemiology. 2-nd edition. Epidemiology Resources Inc., 1990. (Russ. ed.: Ahlbom A., Norell S. Vvedeniye v sovremennuyu epidemiologiyu. Tallin, Institut experimentalnoi i klinicheskoi meditsiny (Estonia); Datskoye protivorakovoye obshestvo, 1996. 122 p.).
10. Beaglehole R., Bonita R., Kjellstrom T. Basic Epidemiology. Geneva, WHO, 1993. (Russ. ed.: Beaglehole R., Bonita R., Kjellstrom T. Osnovy epidemiologii. Geneva, VOZ, 1994. 259 p.).
11. Lakin G.F. Biometry. 4-st edition. Moscow, Higher School Publ., 1990, pp. 254-306. (In Russian).
12. Indicators for assessing iodine deficiency disorders and their control through salt iodization: Document WHO/NUT/94.6. Geneva: WHO, 1994. 56 p.
13. Mean thyroid doses for inhabitants of different age, living in 1986 in settlements of Bryansk, Tula, Oryol and Kaluga regions, contaminated by radionuclides as a result of the Chernobyl accident: guide. Ed.: Balonov M.I., Zvonova I.A. Radiatsiya i risk – Radiation and Risk, 2002, special issue, pp. 3-94. (In Russian).
14. Morshina T.N., Bobovnikova Ts.I., Korpusova Yu.V., Gorobets V.F., Matveenko Ye.G., Tkachenko R.V., Omelchenko V.N., Borovikova M.N. Study of geochemical features of a line of districts of the Kaluga region with endemic goiter. Gigiena i sanitariya – Hygiene and Sanitary, 1994, no. 3, pp. 45-47. (In Russian).
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