Clinical picture of experimental radiation sickness in dogs following chronical exposure to gamma-radiation, administration of Pu-239 and simultaneous exposure to both agents

"Radiation and Risk", 2000, Special Issue, pp.113-117
Selected articles from the journal "Bulletin of Radiation Medicine", 1959, No. 1a, pp. 32-38


Rogacheva S.A., Kudasheva N.P., Oliper T.V., Kalmykova Z.I.


Course of radiation sickness in dogs was studied. The dogs a) were exposed to gamma-radiation in a dose 10 R/day, integrated dose was 1300 R; b) had been administered 239Pu (0.05 μCi/kg monthly, integrated dose 0.2 &muCi/kg) for three months; c) were exposed to both agents. During the follow-up lasted for 8 months two periods were specified: I - period of initial changes (after 2nd-4th week of exposure): unstable changes in specific organs and systems; II - period of marked clinical manifestation (after 2nd-4th month of exposure): stable changes - worsening of general condition, dyspepsia, disturbance of sensitivity, ataxia, advanced changes of morphological composition of peripheral blood, disturbances of secretory stomach functions, marked loss of weight, changes of the cardio-vascular system, hemorhagic diathesis.

Key words
Radiation sickness in dogs, γ-rays, total dose, plutonium, combined effects, changes in the morphological composition of the blood, violation of the secretory function of the stomach, cardiovascular system.


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