Features of pathoanatomical picture of acute radiation sickness in a patient with regard to a type of exposure and radiation dose

"Radiation and Risk", 2000, Special Issue, pp.20-28
Selected articles from the journal "Bulletin of Radiation Medicine", 1961, No. 1a, pp. 88-100

Authors

Lemberg V.K.

Abstract

Pathology picture for 5 patients exposed to radiation as a result of an accident is given. Radiation doses was ranged from 600 to 8600 rem. Three types of the course of acute radiation sickness are described, they are: 1) severe damage of the central nervous system caused by the direct effect of radiation on it at doses exceeded 10000 rem made a main contribution to the clinical picture of the disease and pathogenesis, this was caused by endogenic toxicosis following radiation exposure at doses ranged from 5000 to 10000 rem; 2) intestine damage at doses from 1000 to 5000 rem which made a main contribution to the clinical picture of the disease; 3) damage of haematopoietic system made a main contribution to the clinical picture of the disease - the typical form of acute radiation sickness (less 1000 rem).

Key words
Acute radiation exposure, a wide range of doses, large doses, averaged radiation dose of the organism, radioresistant tissues, repair, proliferative processes.

References

1. Davydovsky I.V. Archive of pathology, 1957, 19, 9, 6.

2. Hempelman L., Lisko G., Hoffman D. Acute radiation syndrome. IL, 1954.

3. Golubitskaya N.N., Lemberg V.K. Bulletin of Radiation Medicine, 1957, 3, 59.

4. Krayevsky N.A. Essays on pathological anatomy of radiation sickness. Moscow, 1957.

5. Kudasheva NP, Levinsky S.V. Bulletin of Radiation Medicine, 1957, 3, 5.

6. Strelin G.S. Medical Radiology, 1956, 1, 1.

7. Namregl N. Virch. Arch. Pathol. Anat., 1936, 298, 376.

8. Onghterson A.W., Warren Sh. Medical effects of the Atomic Bomb in Japan. 1956.

Full-text article (in Russian)