RADIATION & RISK
Bulletin of the National Radiation and Epidemiological Registry
since 1992
About the Journal : 2018 : vol. 27, No. 3 : Prevalence of high-risk carcinogenic human papillomavirus types in women with proved neoplastic lesions in the cervix

Prevalence of high-risk carcinogenic human papillomavirus types in women with proved neoplastic lesions in the cervix

"Radiation and Risk", 2018, vol. 27, No. 3, pp.55-64

DOI: 10.21870/0131-3878-2018-27-3-55-64

Authors

Mkrtchyan L.S. – Lead. Researcher, C. Sc., Med. A. Tsyb MRRC, Obninsk. Contacts: 4 Korolev str., Obninsk, Kaluga region, Russia, 249036. Tel.: +7 (484) 399-32-04; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Kaprin A.D.1 – General Director of NMRRC, Academician of RAS, MD, Prof. NMRC of Radiology, Obninsk.
Ivanov S.A.1 – Deputy General Director, MD, Prof. A. Tsyb MRRC, Obninsk.
Kiseleva V.I. – Lead. Researcher, C. Sc., Med. A. Tsyb MRRC, Obninsk.
Minakova J.V. – Doctor. A. Tsyb MRRC, Obninsk.
Lyubina L.V. – Lead. Researcher, C. Sc., Med. A. Tsyb MRRC, Obninsk.
Bezyaeva G.P. – Researcher. A. Tsyb MRRC, Obninsk.
Panarina L.V. – Researcher. A. Tsyb MRRC, Obninsk.
Zamulaeva I.A. – Head of the Dep., D. Sc., Biol., Prof. A. Tsyb MRRC, Obninsk.
Krikunova L.I. – Head of Dep., MD, Prof. A. Tsyb MRRC, Obninsk.

Abstract

There is solid evidence obtained from epidemiological studies of the etiological role of high-risk carcinogenic human papillomavirus (HPV) in the development of cervical intraepithelial neoplasia (CIN), which in 5-15% of cases ends with invasive cervical cancer (CC). The aim of the study was to determine the prevalence of different types of high risk papillomavirus among women with proved cervical intraepithelial neoplasia and cervical cancer in relation to their age, disease severity and lesion site. Women (465) with morphologically proved CIN I-III (262 patients) and cervical cancer IIII stages (203 patients) were included in the study. A sufficiently high level of HPV was detected among the patients (CIN I-III 64.9%, cervical cancer I-III 87.2%, p<0.0001) with prevalence of 16 (52%) and 33 (10%) genotypes – with CIN I-III, 16 (60%) and 18 (14%) genotypes – with cervical cancer I-III. A statistically significant prevalence of HPV infection with several genotypes was observed in patients with CIN I-III in comparison with cervical cancer of stages I-III, respectively, in 29.9% and 8.2% of cases (p=0.003), with the highest occurrence at the age of 30 years (40.7%). The proportion of infection with HPV type 16 in patients with CIN I-III increased with increasing severity of the pathological process, acquiring a statistically significant character in the transition of moderate changes to intraepithelial cancer of the cervix (p<0.05).

Key words
Human papilloma virus of high carcinogenic risk, cervical intraepithelial neoplasia, cervical cancer, neoplastic processes of the cervix, multiple infection, monoinfection, genotype, radiation contaminated territories.

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