RADIATION & RISK
Bulletin of the National Radiation and Epidemiological Registry
since 1992
About the Journal : 2014 : vol. 23, No. 2 : Shear wave elastography in the differential diagnosis of benign and malignant thyroid nodules

Shear wave elastography in the differential diagnosis of benign and malignant thyroid nodules

«Radiation and Risk», 2014, vol. 23, No. 2, pp.72-84

Authors

Parshin V.S.1 – Head of Dep., MD, Prof., Medical Radiological Research Center, Ministry of Health of the Russian Federation, Obninsk. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: (48439) 9-32-89; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Tarasova G.P.1 – Lead. Programmer, Medical Radiological Research Center, Ministry of Health of the Russian Federation, Obninsk.
Pavlinova E.S.2 – Physician, Central Clinical Hospital, Ministry of Internal Affairs of the Russian Federation, Moscow.

Abstract

Shear wave elastography was performed using the Aixplorer ultrasound system (SuperSonic Imagine, Aix-en-Provence, France) to evaluate patients with thyroid nodules. Tissue stiffness was measured quantitatively in kilopascals (kPa). The data were then used to form an image that was coded in colour: stiffer tissues were coded in red and softer tissues in green and blue.This tech-nique was used to assess the stiffness in 182 regions of the normal thyroid gland without nodules, in 495 regions of thyroid nodules irrespective of their morphology, in 176 regions of benign thyroid tumors, and in 39 regions of malignant thyroid tumors. Nonparametric statistics were used and analyses of receiver operating characteristic (ROC) curve were performed. The median stiffness values were determined to be 15.6 kPa (2,5-97,5 percentiles, range: 6,5-29,7 kPa) for normal thyroid tissues, 17,5 kPa (2,5-97,5 percentiles, range: 0,03-198,2 kPa) for thyroid nodules, 20,1 kPa (2,5-97,5 percentiles, range: 3,6-81,3 kPa) for benign thyroid nodules, and 112,9 kPa (2,5-97,5 percentiles, range: 13,5-196,4 kPa) for malignant thyroid nodules. The cutoff value of 41,1 kPa was found to be optimal for discriminating between malignant and benign nodules with a sensitivity of 84% and a specificity of 81,8%. Statistical processing was performed using SPSS 13,0 Package.

Key words
Thyroid gland, ultrasound, shear wave elastography, differential diagnosis, stiffness cutoff value in kPa.

References

1. Diomidova V.N., Petrova O.V. Sravnitel'nyi analiz rezul'tatov elastografii sdvigovoi volnoi i tranzientnoi elastografii v diagnostike diffuznykh zabolevanii pecheni [Comparative analysis of shear wave elastography and transient elastography in diagnosis of diffuse liver disease]. Ul'trazvukovaia i funktsional'naia diagnostika – Ultrasound and Functional Diagnostics, 2013, no. 5, pp. 17-23.

2. Kotliarov P.M., Kharchenko V.P., Aleksandrov Yu.K., Mogunov M.S., Sencha A.N., Patrunov Yu.N., Beliaev D.V. Ul'trazvukovaia diagnostika zabolevanii shchitovidnoi zhelezy [Ultrasound diagnostics of thyroid diseases]. Moscow, VIDAR, 2009. 239 p.

3. Mit'kov V.V., Khuako S.A., Tsyganov S.E., Kirillova T.A., Mit'kova M.D. Sravnitel'nyi analiz dannykh elas-tografii sdvigovoi volnoi i rezul'tatov morfologicheskogo issledovaniia tela matki (predvaritel'nye rezul'taty) [Comparative analysis of shear wave elastography and results of uterine morphological examination (preliminary results)]. Ul'trazvukovaia i funktsional'naia diagnostika – Ultrasound and Functional Diagnostics, 2013, no. 5, pp. 99-114.

4. Osipov L.V. Tekhnologii elastografii v ul'trazvukovoi diagnostike. Obzor [Technology elastography in ultra-sound diagnostics. Overview]. Diagnosticheskaia radiologiia i onkoterapiia – Diagnostic Radiology and Oncological Therapy, 2013, no. 3-4, pp. 5-23.

5. Parshin V.S., Yamashita S., Tsyb A.F. Zob. Ul'trazvukovaja diagnostika. Klinicheskij atlas [Ultrasound di-agnosis of goiter. Fundamental and clinical Atlas]. Nagasaki-Obninsk, Nagasaki University, 2000. 106 p.

6. Parshin V.S., Tsyb A.F., Yamashita S. Rak shchitovidnoi zhelezy. Ul'trazvukovaia diagnostika. Klinicheskii atlas. Po materialam Chernobylia [Ultrasound diagnosis of thyroid cancer. Fundamental and clinical atlas. Learned from Chernobyl]. Obninsk, MRNTS RAMN, 2002. 230 p.

7. Postnova N.A., Vasil'ev A.Yu. Vozmozhnosti elastografii sdvigovoi volnoi v differentsial'noi diagnostike izmenenii molochnykh zhelez [Value of shear wave elastography in breast lesions differential diagnosis]. Ul'trazvukovaia i funktsional'naia diagnostika – Ultrasound and Functional Diagnostics, 2013, no. 5, pp. 60-71.

8. Sencha A.N., Mogutov M.S., Patrunov Yu.N., Beliaev D.V., Sergeeva E.D., Kashmanova A.V. Kolich-estvennye i kachestvennye pokazateli ul'trazvukovoi elastografii v diagnostike raka shchitovidnoi zhelezy [Quantitative and qualitative characteristics of ultrasound elastography in thyroid cancer diagnosis]. Ul'trazvukovaia i funktsional'naia diagnostika – Ultrasound and Functional Diagnostics, 2013, no. 5, pp. 85-98.

9. Ternovoi S.K., Abduraimov A.B., Les'ko K.A., Lebedev V.V., Abduraimova R.K. Vozmozhnosti mammo-grafii i kachestvennoi elastografii v diagnostike raka molochnoi zhelezy pri gipotireoze [Value of mammography and qualitative elastography in diagnosis of breast cancer in patients with hypothyroidism]. Ul'trazvukovaia i funktsional'naia diagnostika – Ultrasound and Functional Diagnostics, 2013, no. 5, pp. 50-59.

10. Tsyb A.F., Parshin V.S., Yamashita S. Ul'trazvukovaia diagnostika zabolevanii shchitovidnoi zhelezy [Ul-trasound diagnostics of thyroid diseases]. Moscow, Meditsina, 1997. 329 p.

11. Asteria C., Giovanardi A., Pizzocaro A., Cozzaglio L., Morabito A., Somalvico F., Zoppo A. US-elastography in the differential diagnosis of benign and malignant thyroid nodules. Thyroid, 2008, vol. 18, pp. 523-531.

12. Bojunga J., Herrmann E., Meyer G., Weber S., Zeuzem S., Friedrich-Rust M. Real-time elastography for the differentiation of benign and malignant thyroid nodules: a meta-analysis. Thyroid, 2010, vol. 20, pp. 1145-1150.

Full-text article (in Russian)