RADIATION & RISK
Bulletin of the National Radiation and Epidemiological Registry
since 1992
About the Journal : 2014 : vol. 23, No. 2 : Effect of combination of photodynamic therapy and electrochemical lysis

Effect of combination of photodynamic therapy and electrochemical lysis

«Radiation and Risk», 2014, vol. 23, No. 2, pp.28-36

Authors

Mikhailovskaya A.A. – Head of Lab., C. Sc., Biol., Medical Radiological Research Center, Ministry of Health of the Russian Federation, Obninsk. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: +7(48439) 9-70-29; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Kaplan M.A. – Head of Dep., MD, Prof., Medical Radiological Research Center, Ministry of Health of the Russian Federation, Obninsk.

Abstract

Experimental studies demonstrated that combined action of electrochemical lysis in a optimal regimen for intact tissue and photodynamic therapy resulted in more complete tumor destruction. Optimal parameters of electrochemical lysis used in experiments were horizontal position of electrodes, current rate of 30 mA, duration of exposure – 15 minutes. In experiments with electrochemical lysis completeness of tumor destruction achieved 75%. Combined use of electrochemical and photodynamic therapy resulted in 97% of tumor destruction.

Key words
Photodynamc therapy, electrochemical lysis, sarcoma M-1, laser, photosensitizer, «Photolon», complete tumor regression, rats, combined treatment, experimental study.

References

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Full-text article (in Russian)