RADIATION & RISK
Bulletin of the National Radiation and Epidemiological Registry
since 1992
About the Journal : 2011 : vol. 20, No. 2 : Features of radionuclide diagnostics of thyroid cancer: factors affecting results of the radioisotope test

Features of radionuclide diagnostics of thyroid cancer: factors affecting results of the radioisotope test

«Radiation and Risk», 2011, vol. 20, no. 2, pp.36-46

Authors

Gorobets V.F. – Lead. Res., C. Sc., Med. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk. Contacts: 4 Korolyov str., Obninsk, Kaluga Region, Russia, 249036. Tel.: (48439) 9-30-11; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Davydov G.A. – Head of Dep., C. Sc., Med. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Oleinik N.A. – Physician-Radiologist. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Gorobets N.Ya. – Lead. Programmer. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Davydova E.V. – Res. Assistant. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.

Abstract

59 patients with pathologically confirmed thyroid cancer underwent biphase scintigraphy with application of 99mTc-pertechnetate and 99mTc-MIBI prior to operation. The true positive results were detected in 35 patients (59.32%). It was found, that one of the most significant factors which effected the quality of radionuclide imaging was the size of the cancer nodule: images of nodules with diameter >1 cm were of higher quality. As the factor, promoting positive radionuclide diagnostics, serves biological activity of thyroid cancer, which was shown by invasion of increased cancer nodules to surrounding tissues and/or the presence of metastases. The factor, complicating radionuclide diagnostics of cancer nodules, was the presence of accompanying non-cancer thyroid diseases.

Key words
Thyroid cancer, radionuclide diagnostics, size of cancer nodules, biological activity of malignant tumors, accompanying non-cancer thyroid diseases.

References

1. Abdulkhalimova M.M., Mitkov V.V., Bondarenko V.O., Zubarev A.R. Diagnosis of nodal thyroid glandular formation using modern research methods. Ultrasonic diagnostics. 1999. No. 3. PP. 69-81.

2. Akhmedova F.B., Filatov A.A. Radiation Diagnosis of Thyroid Cancer. Med. radiology and radiation. security. 2003. Vol. 48, no. 3. PP. 41-48.

3. Bronshtein M.E. Thyroid cancer. Problems of endocrinology. 1997. Vol. 43, no. 6. PP. 33-37.

4. Zaitseva T.I., Lyubaev V.L., Shiryaev S.V., Tlish E.H. Radionuclide Diagnosis of Thyroid Cancer. Med. radiology and radiation. security. 2003. Vol. 48, no. 5. PP. 51-61.

5. Zelenin A.A., Orlov S.A., Gareev M.M. Possibilities of preoperative determination of oncological pathology of the thyroid gland. Radiology 2005: Proceedings of the VI All-Russian Scientific Forum. Moscow, 2005. P. 138.

6. Ivanov V.K., Tsyb A.F. Medical radiological consequences of Chernobyl for the population of Russia: assessment of radiation risks. Moscow, Medicine, 2002. 392 p.

7. Kolokasidis I.V. Magnetic resonance imaging with nodular thyroid formations: author's abstract. diss. ... Cand. med. sciences. Moscow, 1999. 16 p.

8. Lakin G.F. Biometrics. Ed. 4th. Moscow, Higher School Publ., 1990. PP. 120-123.

9. Oleinik V.A., Bezverkhaya T.P., Epstein E.V., Boguchok Yu.M. Diagnosis of thyroid cancer. Problems of endocrinology. 1995. Vol. 41, no. 5. PP. 37-41.

10. Oleinik N.A., Rumyantsev P.O., Ilyin A.A. et al. The use of technetril (MIBI) in diagnosis of thyroid gland and metastases of papillary thyroid cancer in the lymph nodes of the neck. Med. radiology and radiation safety. 1999. Vol. 44, No. 1. PP. 35-43.

11. Parshin V.S. Ultrasonic screening of the thyroid gland: dis. ... Doct. med. sciences. Obninsk, 1994. 205 p.

12. Parshkov E.M., Sokolov V.A., Proshin A.D., Stepanenko V.F. Thyroid cancer in children and adults in the Bryansk region after the Chernobyl accident. Oncology. 2004. Vol. 50, no. 5. PP. 533-539.

13. Pinsky S.B., Dvornichenko V.V., Beloborodov V.A. Tumors of the thyroid gland. Irkutsk, 1999. 320 p.

14. Semenov V.D., Alekseev S.V., Sverchkova L.A. Scintigraphy in the Diagnosis of Volume Damage of the Thyroid Gland. Radiology 2005: Proceedings of the VI All-Russian Scientific Forum. Moscow, 2005. P. 399.

15. Semenov V.D., Sverchkova L.A., Pavlova Yu.N. Scanno- and scintigraphy in the diagnosis of thyroid autonomy. Radiology 2006: Proceedings of the VII All-Russian Scientific Forum. Moscow, 2006. PP. 217-218.

16. Ultrasound diagnosis of thyroid diseases. A.F. Tsyb, V.S. Parshin, G.V., Nestayko et al. Moscow, Medicine Publ., 1997. 332 p.

17. Kharchenko V.P., Kotlyarov P.M., Fomin D.K., Mikheeva N.V. Two-indicator radionuclide diagnostics of malignant thyroid diseases. Med. radiology and radiation safety. 2007. Vol. 52, no. 5. PP. 54-60.

18. Alonso O., Lago G., Mut F. et al. Thyroid imaging with Tc-99m-MIBI in patients with solitary cold single nodules on pertechnetate imaging. Clin. Nucl. Med. 1996. Vol. 21, No. 5. PP. 363-367.

19. Danese D., Centanni M., Farsetti A., Andreoli M. Diagnosis of thyroid carcinoma. J. Exp. Clin. Cancer Res. 1997. Vol. 16, no. 3. PP. 337-347.

20. Sundram F., Goh A., Ang E. Role of technetium-99m-sestamibi in localization of thyroid cancer metastases. Ann. Acad. Med. Singapore. 1993. Vol. 22, no. 4. PP. 557-559.

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