Features of radionuclide diagnostics of thyroid cancer: factors affecting results of the radioisotope test

«Radiation and Risk», 2011, vol. 20, no. 2, pp.36-46

Authors

Gorobets V.F. – Lead. Res., C. Sc., Med. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk. Contacts: 4 Korolyov str., Obninsk, Kaluga Region, Russia, 249036. Tel.: (48439) 9-30-11; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Davydov G.A. – Head of Dep., C. Sc., Med. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Oleinik N.A. – Physician-Radiologist. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Gorobets N.Ya. – Lead. Programmer. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Davydova E.V. – Res. Assistant. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.

Abstract

59 patients with pathologically confirmed thyroid cancer underwent biphase scintigraphy with application of 99mTc-pertechnetate and 99mTc-MIBI prior to operation. The true positive results were detected in 35 patients (59.32%). It was found, that one of the most significant factors which effected the quality of radionuclide imaging was the size of the cancer nodule: images of nodules with diameter >1 cm were of higher quality. As the factor, promoting positive radionuclide diagnostics, serves biological activity of thyroid cancer, which was shown by invasion of increased cancer nodules to surrounding tissues and/or the presence of metastases. The factor, complicating radionuclide diagnostics of cancer nodules, was the presence of accompanying non-cancer thyroid diseases.

Key words
Thyroid cancer, radionuclide diagnostics, size of cancer nodules, biological activity of malignant tumors, accompanying non-cancer thyroid diseases.

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