RADIATION & RISK
Bulletin of the National Radiation and Epidemiological Registry
since 1992
About the Journal : 2008 : vol. 17, No. 3 : Consequences for reproductive function of the unitary irradiation in not sterilizing doze antenatal and sexual maturity ovaries rats Wistar

Consequences for reproductive function of the unitary irradiation in not sterilizing doze antenatal and sexual maturity ovaries rats Wistar

«Radiation and Risk», 2008, vol. 17, no. 3, pp.46-53

Authors

Palyga G.F. - Department Head, M.D. Medical Radiological Research Center of RAMS, Obninsk. Contacts: 249036, Kaluga Region, Obninsk, ul. The Queen, 4. Tel .: (48439) 7-47-80; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Chibisova O.F. - Researcher. Medical Radiological Research Center of RAMS, Obninsk.
Ivanov V.L. - Senior Researcher. Medical Radiological Research Center of RAMS, Obninsk.

Abstract

In researches on 402 rats Wistar, more than 1300 fruits and 1900 young rats posterities of the first generation are investigated reproductive function of the animals, subjected to unitary total gamma irradiation 60Со in not sterilizing doze 1 Gy (capacity of a doze 0,003sGy/s) for 10 day of their intra-uterine development (the period of a bookmark of reproductive system) or in various terms (1, 4-11 and 30-40 day) after radiating influence on sexual maturity females. Posterity females, irradiated antenatal, or posterity sexual maturity animals, pregnancy at which came in the first 11 day after an irradiation, defectively, and this inferiority is more expressed in postnatal ontogenesis at posterity on a parent line antenatal the irradiated animals.

Key words
Rats Wistar; irradiation of antenatal and sexual maturity ovaries; reproductive function; posterity.

References

1. Dubrova Yu.E. Instability of the genome among descendants of irradiated parents. The facts and their interpretation. Genetics. 2006. Vol. 42, No. 10. pp. 1-10.

2. Palyga G.F., Zakoschikov K.F., Epatova Т.V. Influence of total gamma irradiation of females on pregnancy and postnatal development of offspring. Archive of anatomy, histology and embryology. 1984. Vol. LXXXVII, No. 12. PP.71-76.

3. Svetlov P.G., Korsakova G.F. Pathogenic effect of ionizing radiation on rat embryogenesis. Influence of ionizing radiation on the course of pregnancy, the state of the fetus and the newborn. Leningrad, Medgiz Publ., 1960. PP. 37-72.

4. Shakhdinarova L.V., Palyga G.F. Long-term effects of irradiation of ovaries in rats during embryonic development. Radiobiology. 1989. Vol 29, no. 2. PP. 175-178.

5. Baskar R., Devi P.U. Influence of gestational age to low-level gamma irradiation on postnatal behavior in mice. Neurotoxicology and Teratology. 2000. Vol. 22, no. 4. PP. 593-602.

6. Martinez Flores I., Saez C., Egozcue J. et al. Effect of ionizing radiation on oocytes of prepubertally irradiated rats. International Journal of Radiation Biology. 2000. Vol. 76, no. 10. PP. 1403-1407.

7. Wang B., Ohyama H., Haginoya K. et al. Adaptive response in embryogenesis: II. Retardation of postnatal development of prenatally irradiated mice. Radiation Research. 1999. Vol. 152, No. 2. PP. 119-123.

Full-text article (in Russian)