Hemostasis values of liquidators of the Chernobyl accident and changes in these characteristics with E-25 therapy

«Радиация и риск». 1994. Том 4, с.78-83

Authors

Chekalina S.I., Lyasko L.I., Sushkevich G.N., Nilova E.V.
Medical Radiological Research Center RAMS, Obnins

Abstract

The status of hemostasis system was studied in people who took part in mitigating the consequences of the Chernobyl accident about 4 years ago. We found activation of intravascular coagulation, increase in thromboxane and renin content, reduction of blood fibrinolytic activity, prostacyclin, 60 -keto PGF1α/thromboxane ratio and cyclic nucleotides with disturbances of theiratior towards relative increase of cAMP. The method of functional load allowed us to detect a decrease in antiaggregation activity of vascular walls and reserve potential of fibrinolysis system indicating the decompensation character of in the functional state of hemostatic hemostasis. After E-25 therapy, the system values have not come to normal. This type of disturbance requires patogenetical correction. .

Key words
Functional state, hemostasis system, elimination of consequences, the Chernobyl NPP accident, activation of intravascular coagulation, increased thromboxane, renin levels, decreased blood fibrinolytic activity, prostacyclin, 60-keto PGF1 * / thromboxane ratio, cyclic nucleotides, reduced antiaggregative activity, wrinkles, wrinkles, wrinkles, deplosion of anti-aggregation activity, wrinkles, depreciation of anti-inflammatory activity reserve capacity, fibrinolysis system.

References

1. Avetisov G.M., Aleksakhin R.M., Androsov A.S. and others. Statement by a group of scientists working in the field of radiation safety. Medical radiology. 1990. Vol. 35, N 1. S. 7.

2. A.S. 1084010 USSR. Baluda V.P. et al. (THE USSR). B.I. 1984. No.13. S. 17.

3. Baluda M.V. Platelet-vascular link of the hemostasis system in patients with coronary artery disease under conditions of emotional stress: Dis ... Cand. honey. sciences. M., 1984.

4. Berdov B.A., Pavlov V.V., Chekalina S.I. et al. Prevention of thromboembolic complications in cancer patients: Method. recom. Obninsk, 1986.

5. Gritsay N.N., Mishchenko V.P. et al. Physiology and pathology of hemostasis. Proc. of the All-Union conference. Poltava, 1991. p. 188.

6. Zhukova N.A., Tlepshukov I.K., Baluda V.P. Lesion and restoration of hematopoiesis in acute radiation sickness: Proc. report All-Union. conference M., 1990. P. 100.

7. Lyusov V.A., Katyshkina N.I., Sobolev V.N. et al. Physiology and pathology of hemostasis. Proc. of the All-Union. conference. Poltava, 1991. p. 17.

8. Lyasko, LI, Chekalina, SI, Sushkevich, GN, Parshkov, EM. Physiology and pathology of hemostasis. Proc. of the All-Union conference. Poltava, 1991. p. 171.

9. Handbook of clinical laboratory research methods. Ed. Kost E.A. M., 1971.

10. Chekalina, SI, Tokarev, O. Yu. Micromethods for determining aggregation and adhesion of capillary blood: Method. recom. M., 1983.

11. Chekalina S.I. Functional method of studying the fibrinolysis system for activation: Dis ... Cand. med. sciences. M., 1967.

12. Chekalina SI, Guseva LI, Zubova N.D. Med. radiology. 1982. No. 8. P. 73.

13. Tsyb A.F., Ivanov V.K., Airapetov S.A. et al. Herald AMN. 1991. No.11. PP. 32.

14. Tsyb A.F., Ivanov V.K., Airapetov S.A. et al. Med. radiology. 1992. No.1. PP. 46.

15. Shishmarev Yu.N., Alekseev G.I., Nikiforov A.M. et al. Radiobiology. 1992. Vol. 32, No.3. P. 323.

16. Astrup T. International Congress of Biochemistry. Wien, 1958. P. 40.

17. Bernik M.J., Kwaan H.J. Am.J.Physiol. 1971. Vol. 221. P. 916.

18. Kwaan H.G., Mc. Fadzean A.J. Clin. Sci. 1956. Vol.15. Р. 246.

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