Risk of malignant neoplasms in the first generation offspring of female workers of Mayak Production Association

«Radiation and Risk», 2021, vol. 30, No. 4, pp.143-155

DOI: 10.21870/0131-3878-2021-30-4-143-155

Authors

Sosnina S.F. – Senior Researcher, C. Sc., Med. Contacts: 19 Ozyorskoe shosse, Ozyorsk, Chelyabinsk region, 456780, Russia. Tel.: 8 (35130) 7-16-52; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Okatenko P.V. – Head of Group
Sokolnikov M.E. – Head of Dep., MD. SUBI.
Southern Urals Biophysics Institute, FMBA of the RF (SUBI), Ozyorsk

Abstract

The study of the role of parental preconception exposure in development of malignant neoplasms (MN) in the offspring is a topical point in cancerogenic factors’ research. The objective of the work is assessment of cancer risk among the offspring of female workers of the country’s first atomic production facility – Mayak Production Association (PA) – exposed to long-term occupational radiation exposure prior to conception. We have performed a retrospective epidemiological analysis in a cohort of offspring born in 1949-1990 that contained 2061 children from 1404 female workers. Mothers of 1145 children (55.6%) had accumulated doses of preconception external gamma-exposure to the ovaries (main group); the remaining 916 children (44.4%) were regarded as internal control (compar-ison group) as the offspring of female workers that were not exposed to preconception irradiation of genital organs. We have followed up the vital status and cancer incidence in the offspring up to 31.12.2018. We have performed an analysis of the structure and cancer incidence rates. We had calculated the relative risk (RR) and the excess relative risk (ERR) to a dose unit of external gamma-exposure with a 95% confidence interval using the AMFIT module of the EPICURE software. A total of 92 MN cases were registered in 1949-2018 among the first generation offspring of female workers. A comparative analysis of cancer incidence showed no significant difference in the structure and incidence rate of MN in the groups. The only exception were the offspring of the females not exposed to preconception occupational irradiation of genital organs; in this group we had indicated a significant increase of brain MN in male offspring and of the MN of corpus uteri among female offspring. We had registered MN of digestive organs and MN of breast most often in the main group of the offspring. The range of maternal doses of preconception external gamma-exposure to the ovaries varied greatly: maximum dose in male offspring reached 2954.82 mGy and 4075.61 in female offspring. Calculation of RR of MN in the offspring of the main group showed no significant difference from the comparison group for all the MN, for solid cancers separately, and for other most frequent cancers. Assessment of ERR coefficients in relation to maternal accumulated absorbed dose of preconception external gamma radiation to the ovaries had revealed no statistically significant increase of cancer incidence among the offspring of female workers exposed to occupational irradiation of genital or-gans. We had obtained no reliable evidence in our investigation of the relation between MN in the offspring of Mayak PA female workers and accumulated doses of preconception external gamma-exposure to the gonads. Further research is needed taking into account relatively young average age of the observed cohort of the offspring.

Key words
malignant neoplasms, cancer incidence, preconception radiation exposure, cohort of staff descendants, Mayak PA, maternal exposure, external gamma irradiation, gonad dose, offspring of the exposed, cancer risk, relative risk, excess relative risk.

References

1. Lewandowska A.M., Rudzki M., Rudzki S., Lewandowski T., Laskowska B. Environmental risk factors for cancer – review paper. Ann. Agric. Environ. Med., 2019, vol. 26, no. 1, pp. 1-7.

2. Kolyadina I.V., Poddubnaya I.V. Breast cancer immunology: theory and prospects (review). Sovremennaya onkologiya – Journal of Modern Oncology, 2015, vol. 17, no. 1, pp. 12-18. (In Russian).

3. Osipov M.V. Diagnostic exposure and radiogenic risk. Medline.ru, 2020, vol. 21, no. 1, pp. 423-441. (In Russian).

4. Li L., Kim J.H., Park H.T., Lee J.H., Park M.K., Lee J.W., Lee J.C., Lee M.J. Effect of ionizing radiation at low dose on transgenerational carcinogenesis by epigenetic regulation. Lab. Anim. Res., 2017, vol. 33, no. 2, pp. 92-97.

5. Milne E., Greenop K.R., Fritschi L., Attia J., Bailey H.D., Scott R.J., Ashton L.J., Smibert E., Armstrong B.K. Childhood and parental diagnostic radiological procedures and risk of childhood brain tumors. Cancer Causes Control, 2014, vol. 25, no. 3, pp. 375-383.

6. Ozasa K., Grant E.J., Kodama K. Japanese legacy cohorts: the Life Span Study atomic bomb survivor cohort and survivors' offspring. J. Epidemiol., 2018, vol. 28, no. 4, pp. 162-169.

7. Koterov A.N., Biryukov A.P. The offspring of liquidators of Chernobyl atomic power station accident. Part 1. The estimation of the basic opportunity to register of radiation effects. Meditsinskaya radiologiya i radiatsion-naya bezopasnost’ – Medical Radiology and Radiation Safety, 2012, vol. 57, no. 1, pp. 58-79. (In Russian).

8. Baleva L.S., Nomura T., Sipyagina A.E., Karakhan N.M., Yakusheva E.N., Egorova N.I. Cytogenetic effects and possibilities of their transgenerational transfer in the generations of persons living in radionuclide polluted areas after the Chernobyl accident. Rossiyskiy vestnik perinatologii i pediatrii – Russian Bulletin of Perinatology and Pediatrics, 2016, no. 3, pp. 87-94. (In Russian).

9. Bunch K.J., Muirhead C.R., Draper G.J., Hunter N., Kendall G.M., O’Hagan J.A., Phillipson M.A., Vincent T.J., Zhang W. Cancer in the offspring of female radiation workers: a record linkage study. Br. J. Cancer, 2009, vol. 100, no. 1, pp. 213-218.

10. Kendall G.M., Bithell J.F., Bunch K.J., Draper G.J., Kroll M.E., Murphy M.F.G., Stiller C.A., Vincent T.J. Childhood cancer research in Oxford III: the work of CCRG on ionising radiation. Br. J. Cancer, 2018, vol. 119, no. 6, pp. 771-778.

11. Koshurnikova N.A., Shilnikova N.S., Okatenko P.V., Kreslov V.V., Bolotnikova M.G., Sokolnikov M.E., Khokhriakov V.F., Suslova K.G., Vassilenko E.K., Romanov S.A. Characteristics of the cohort of workers at the Mayak nuclear complex. Radiat. Res., 1999, vol. 152, no. 4, pp. 352-363.

12. Petrushkina N.P., Koshurnikova N.A., Kabirova N.R., Okatenko P.V., Khokhryakov V.V. Radiation risk assessment for communities living near the atomic plants. Report 1. Procedures of radiation risk assessments. Children Register. Voprosy radiatsionnoy bezopasnosti – Radiation Safety Problems, 1996, no. 2, pp. 46-50. (In Russian).

13. Fomin E.P., Okatenko P.V., Koshurnikova N.A. Retrospective development of the Cancer Register for Ozyorsk population and its use at analyzing morbidity rate of malignant tumors over the period from 1948 to 2005. Voprosy radiatsionnoy bezopasnosti – Radiation Safety Problems, 2007, no. 4, pp. 54-62. (In Russian).

14. Napier B.A. The Mayak Worker Dosimetry System (MWDS-2013): an introduction to the documentation. Radiat. Prot. Dosimetry, 2017, vol. 176, no. 1-2, pp. 6-9.

15. Preston D.L., Lubin J.H., Pierce D.A. EPICURE User`s Guide. Seattle, Hirosoft International Corp., 1993. 330 p.

16. Machin D., Campbell M.J., Tan S.B., Tan S.H. Sample Sizes for Clinical, Laboratory and Epidemiology Studies. Fourth Edition. Hoboken, NJ, Wiley, 2018. 409 p.

17. Narkevich A.N., Vinogradov K.A. Methods for determining the minimum required sample size in medical research. Sotsialnye aspekty zdorovya naseleniya – Social Aspects of Population Health [online edition], 2019, vol. 65, no. 6, p. 10. Available at: http://vestnik.mednet.ru/content/view/1123/30/lang,ru/ (Accessed 26.03.2021). (In Russian).

18. Sosnina S.F., Kabirova N.R., Sokol’nikov M.E., Okatenko P.V. Hemoblastoses in offspring of radiation-hazardous industries workers. Analiz riska zdorov’yu – Health Risk Analysis, 2016, no. 4, pp. 23-30. (In Russian).

19. Zhukovskaya E.V., Spichak I.I., Basharova E.V., Volosnikov D.K., Kovalenko S.G., Ogoshkova I.A. Incidence and prevalence of leukemia in children of Chelyabinsk region in 1974-2003 period. Voprosy gematologii/onkologii i immunopatologii v pediatrii – Pediatric Hematology/Oncology and Immunopathology, 2005, vol. 4, no. 1, pp. 20-24. (In Russian).

20. Sosnina S.F., Okatenko P.V. Consequences of maternal preconceptional exposure: solid cancers in offspring in the first generation. Radiatsiya i risk – Radiation and Risk, vol. 28, no. 3, pp. 132-144. (In Russian).

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