Analysis of clinical and epidemiological indicators of peripheral artery disease in patients living in close vicinity of uranium legacy sites

«Radiation and Risk», 2021, vol. 30, No. 2, pp.146-157

DOI: 10.21870/0131-3878-2021-30-2-146-157

Authors

Suranova G.J. – Ass. Prof., C. Sc., Med. IHSM. *Contacts: 86 Bakayev str., Bishkek, Kyrgyzstan, 720047. Tel. 0 (996) 555-751490; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Tuhvatshin R.R. – Head od Dep., MD, Prof. I.K. Akhunbayev KSMA.
International Higher School of Medicine, Bishkek, Kyrgyzstan
¹ I.K. AKhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan

Abstract

The article presents results of clinical and epidemiological analysis of medical records of patients lived in the vicinity of uranium legacy sites and suffered from peripheral artery disease. The records of 474 patients were examined, 40 of the patients were included in the main group. The control groups 1 and 2 contained 434 patients lived in conditionally "clean" sites, free of waste deposited in low and middle altitude sites. The results demonstrate prevalence of multilevel occlusive lesions of the arteries of the lower extremities group with involvement in the pathological process and distal segments of the vessels (OR=6.26; X²=24.92 and OR=5.56; X²=16.7; p<0.001) in patients of the main group. The higher frequency of critical lower limb ischemia in the main group compared to the control group 2 by 1.42 times (p>0.05) indirectly points to the exertion of altitude adaptation mechanisms in patients living in radionuclide-free (OR=5.38; X²=14.22; p<0.001) and manifestations of chronic ischemia (p>0.05) in the main group exceeded the number in other groups under study allows making sugges-tion that there were lesions on arterial walls in the main group patients. Femoral-anteriortibial bypass surgery was implemented more frequently (OR=2.73, X²=5.49, p=0.02; OR=5.35, X²=9.09, p=0.003) in patients of the main group, this fact can be considered as the further confirmation of the presence of damage to the distal parts of the vessels. Based on the study analysis, one can draw conclusion that peripheral artery disease had specific pathogenesis and clinical features in the patients lived in the vicinity of radioactive waste storage sites with standard levels of radiation background and mountain climate.

Key words
clinical epidemiology, uranium legacy, radionuclides, mountain adaptation, cardiovascular system, peripheral artery disease, skeletal muscles, lower limb arteries, femoral-popliteal segment, chronic lower limb ischemia, critical ischemia, intermittent claudication.

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