Pharmacokinetics of 68Ga-NODA-aminoglucose in mice with Ehrlich carcinoma

«Radiation and Risk», 2020, vol. 29, No. 3, pp.60-70

DOI: 10.21870/0131-3878-2020-29-3-60-70


Tishchenko V.K. – Lead. Researcher, C. Sc., Biol.
Petriev V.M. – Head of Lab., D. Sc., Biol., Prof. of MEPhI. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249035. Tel.: (484) 399-71-00; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Mikhailovskaya A.A. – Sen. Researcher, C. Sc., Biol.
Fedorova A.V. – Lead. Engineer
Stepchenkova E.D. – Junior Researcher
Ekatova T.Yu. – Junior Researcher. A. Tsyb MRRC.

1 A. Tsyb MRRC, Obninsk
2 National Research Nuclear University MEPhI, Moscowk


The clinical application of Positron Emission Tomography (PET) is growing in Russia. To increase the accessibility of PET-procedures for the general public, the development of cost-effective radiotracers has become of particular importance. The paper presents results of the study of pharmaco-kinetic properties of the new compound contained based on NODA-aminoglucose and generate radionuclide gallium-68 (68Ga-NODA-AG). Intact outbred mice and mice with subcutaneously inoculated Ehrlich carcinoma were taken in the study. Concentration of 68Ga-NODA-AG was measured by direct radiometry. The same method was used for calculation of biological and effective half-lives of the radiopharmaceutical. Binding efficacy of 68Ga with NODA-AG was above 95%. The content of radiochemical impurities was less than 5%. Specific activity of 68Ga-NODA-AG in the tumor reduced from 3.19 %/g in 5 minutes after the radiotracer administration to 0.93 %/g, 0.34 %/g and 0.31 %/g in 1, 2, 3 hours respectively. Because an increased amount of radioactivity is accumulated in the tumor as compared with healthy tissues and organs the rate of 68Ga-NODA-AG clearance from the tumor tissue was relatively low. The compound was cleared by renal route. It should be stressed that 68Ga-NODA-AG concentration in the brain and the heart was low. Accumulation of radioactivity in tumor-bearing mice was lower than in intact animals mainly at early stages of the study. Biological and effective half-lives of the radiopharmaceutical in all organs and tissues except for the brain were higher in tumor-bearing mice than in intact animals. The obtained results allow making the following conclusion: the pharmacokinetic properties of 68Ga-NODA-AG are optimal for diagnostic radiopharmaceuticals.

Key words
gallium-68, aminoglucose, positron emission tomography, Ehrlich carcinoma, radio-pharmaceutical, biological and effective half-lives.


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