Consequences of maternal preconceptional exposure: solid cancers

«Radiation and Risk», 2019, vol. 28, No. 3, pp.132-144

DOI: 10.21870/0131-3878-2019-28-3-132-144

Authors

Sosnina S.F – Researcher, C. Sc., Med. Contacts: 19 Ozersk road, Ozersk, Chelyabinsk region, Russia, 456780.
Tel.: +7(35130) 7-66-27, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Okatenko P.V. – Head of Computer and Software Support Group. SUBI.

Southern Urals Biophysics Institute, FMBA, Ozersk.

Abstract

Preconceptional exposure of parents is considered as a potential carcinogenic factor for offspring. This paper presents comparative analysis of the incidence of solid cancers in the offspring of female workers of the Production Association "Mayak", subjected to prolonged preconceptional radiation exposure in their workplace. We carried out retrospective analysis in the group of offspring born in 1949-2004, including 4303 children from 2691 mothers. We traced the vital status and cancer incidence of offspring until December 31, 2014. The number of person-years of the follow-up cohort amounted to 138072.3. We analyzed the structure of solid cancers, "rough" and standardized by age and sex incidence rates. For comparative analysis of cancer incidence the method of indirect standardization was used, we applied regional and national standards, the module AMFIT of EPICURE software. The range of accumulated preconceptual doses of external gamma radiation of mothers was 0.01-5062.64 mGy with an average dose to the whole body 387.07 mGy, the dose to the gonads – 299.72 mGy. One third of mothers had accumulated preconceptual doses of internal alpha radiation to the gonads with the highest dose to ovaries of 102.52 mGy. For 65 years (from 1949 to 2014) 116 cases of solid malignant neoplasms were diagnosed in the cohort of offspring of female workers of Mayak PA. The average age of the first cancer cases at diagnosis was 46.6 years. Incidence rates of solid cancers diagnosed among the offspring of both sexes and thyroid cancer among women exceeded the rates of the national and regional statistics. There was a significant increase in thyroid cancer incidence among women older than 15 years in comparison with national data – 2.33 (1.00-4.51). Malignant brain tumors in the offspring of both sexes older than 15 years significantly exceeded the national standard: among men – 4.13 (1.64-8.37), among women – 3.58 (1.11-8.32) and the regional standard among men older than 15 years – 3.51 (1.39-7.10). Conclusion: We assume that maternal preconceptual radiation exposure plays a certain role in the development of oncopathology in children, which requires continued monitoring of the cohort of the Mayak Production staff offspring.

Key words
preconceptual radiation exposure, maternal exposure, solid tumors, the offspring of the irradiated mothers, cancer incidence standardized by age and sex, Mayak PA.

References

1. Solenova L.G. Faktory onkologicheskogo riska u detey i podkhody k profilaktike ikh vozdeystviya [Cancer risk factors in children and approaches to the prevention of their effects]. Pediatriya. Zhurnal im. G.N. Speranskogo – Pediatrics. Journal Named after G.N. Speransky, 2011, vol. 90, no. 4, pp. 120-126.

2. Paris L., Giardullo P., Leonardi S., Tanno B., Meschini R., Cordelli E., Benassi B., Longobardi M.G., Izzotti A., Pulliero A., Mancuso M., Pacchierotti F. Transgenerational inheritance of enhanced susceptibility to radiation-induced medulloblastoma in newborn Ptch1⁺/^- mice after paternal irradiation. Oncotarget, 2015, vol. 3, no. 6, pp. 36098-36112.

3. Suman S., Kumar S., Moon B.H., Fornace A.J., Kallakury B.V.S., Datta K. Increased transgenerational intestinal tumorigenesis in offspring of ionizing radiation exposed parent APC1638N/+ mice. J. Cancer, 2017, vol. 8, no. 10, pp. 1769-1773.

4. Johnson K.J., Alexander B.H., Doody M.M., Sigurdson A.J., Linet M.S., Spector L.G., Hoffbeck W., Simon S.L., Weinstock R.M., Ross J.A. Childhood cancer in the offspring born in 1921-1984 to US radiologic technologists. Br. J. Cancer, 2008, vol. 99, no. 3, pp. 545-550.

5. Little M.P., Goodhead D.T., Bridges B.A., Bouffler S.D. Evidence relevant to untargeted and transgenerational effects in the offspring of irradiated parents. Mutat. Res., 2013, vol. 753, no. 1, pp. 50-67.

6. Grant E.J., Furukawa K., Sakata R., Sugiyama H., Sadakane A., Takahashi I., Utada M., Shimizu Y., Ozasa K. Risk of death among children of atomic bomb survivors after 62 years of follow-up: a cohort study. Lancet Oncol., 2015, vol. 16, no. 13, pp.1316-1323.

7. Evtushenko N.N., Volosnikov D.K., Akleyev A.V. Fizicheskoye razvitiye detey pervogo goda zhizni, roditeli kotorykh podvergalis’ khronicheskomu radiatsionnomu vozdeystviyu [Physical development of children of the first year of life whose parents were exposed to chronic radiation exposure]. Pediatriya. Zhurnal im. G.N. Speranskogo – Pediatrics. Journal Named after G.N. Speransky, 2010, vol. 89, no. 6, pp. 52-57.

8. Naydich V.I. Osnovnyye rezul’taty nauchnykh issledovaniy v oblasti radiobiologii za 2017 god [The main results of scientific research in the field of radiobiology for 2017]. Radiatsionnaya biologiya. Radioekologiya – Radiation Biology. Radioecology, 2018, vol. 58, no. 3, pp. 320-336.

9. Sosnina S.F., Okatenko P.V. Neinfektsionnaya patologiya u detey rabotnits predpriyatiya atomnoy promyshlennosti [Non-infectious pathology in children of female workers of nuclear industry enterprise]. Meditsinskiy akademicheskiy zhurnal – Medical Academic Journal, 2017, vol. 17, no. 3, pp. 68-76.

10. Fomin E.P., Okatenko P.V., Koshchurnikova N.A. Opyt retrospektivnogo sozdaniya kantser-registra dlya naseleniya g. Ozerska i analiz pokazateley zabolevayemosti zlokachestvennymi novoobrazovaniyami na ego osnove za period s 1948 po 2005 gg. [The experience of the retrospective creation of a cancer registry for the population of Ozersk and the analysis of the incidence rates of malignant neoplasms based on it for the period from 1948 to 2005]. Voprosy radiatsionnoy bezopasnosti – Questions of Radiation Safety, 2007, no. 4, pp. 54-62.

11. Petrushkina N.P., Koshchrnikova N.A., Kabirova N.R., Okatenko P.V., Khokhryakov V.V. Otsenka radiatsionnogo riska dlya naseleniya, prozhivayushchego vblizi predpriyatiya atomnoy promyshlennosti. Soobshcheniye 1. Metodicheskiye podkhody k otsenkam radiatsionnogo riska. Sostav Detskogo Registra [Radiation risk assessment for the population living near the nuclear industry. Report 1. Methodical ap-proaches to radiation risk assessments. Composition of the Children's Register]. Voprosy radiatsionnoy bezopasnosti – Questions of Radiation Safety, 1996, no. 2, pp. 46-50.

12. Vasilenko E.K. Dozimetriya vneshnego oblucheniya rabotnikov PO «Mayak»: pribory, metody, rezul’taty [Dosimetry of external exposure of Mayak PA workers: devices, methods, results]. Istochniki i effekty oblucheniya rabotnikov PO «Mayak» i naseleniya, prozhivayushchego v zone vliyaniya predpriyatiya, pod red. M.F. Kiseleva, S.A. Romanova [Sources and effects of irradiation of workers of the PA Mayak and the population living in the zone of influence of the enterprise. Eds.: M.F. Kiselev, S.A. Romanov]. Chelyabinsk: Chelyabinsk printing house, 2009, part 1, pp. 51-100.

13. Statisticheskaya klassifikatsiya bolezney, travm i prichin smerti (adaptirovannyy variant MKB-9 dlya ispol’zovaniya v SSSR) [Statistical classification of diseases, injuries and causes of death (adapted version of the ICD-9 for use in the USSR]. Edition 2. Moscow, 1986. 97 p.

14. Mezhdunarodnaya statisticheskaya klassifikatsiya bolezney i problem, svyazannykh so zdorov’yem. Desyatyy peresmotr, tom 1 (chast’ 2) [International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Vol. 1]. Moscow, Medicina, 1995. 633 p.

15. Davydov M.I., Aksel’ E.M. Zlokachestvennyye novoobrazovaniya v Rossii i stranakh SNG v 2001 g. [Malig-nant neoplasms in Russia and the CIS countries in 2001]. Moscow: Medical information agency, 2003. 296 p.

16. Chissov V.I., Starinskiy V.V., Petrova G.V. Zlokachestvennyye novoobrazovaniya v Rossii v 2010 godu (zabolevayemost’ i smertnost’) [Malignant neoplasms in Russia in 2010 (morbidity and mortality)]. Moscow, FGBU MNIOI named after P.A. Gertsen of Rosmedtechnologies, 2012. 260 p.

17. Vazhenin A.V., Tyukov Yu.A., Pshichenko S.V. Zabolevayemost’ i smertnost’ ot zlokachestvennykh novoobrazovaniy, organizatsiya onkologicheskoy pomoshchi naseleniyu Chelyabinskoy oblasti v 2014 g. [Morbidity and mortality from malignant tumors, organization of cancer care to the population of the Chelya-binsk region in 2014]. Chelyabinsk, Chelyabinsk Regional Clinical Oncology Center of the Ministry of Health of the Chelyabinsk Region, 2015. 77 p.

18. Preston D.L., Lubin J.H., Pierce D.A. EPICURE User`s Guide. Seattle: Hirosoft International Corp., 1993. 330 p.

19. Serenko A.F., Tserkovnyy G.F. Zlokachestvennyye novoobrazovaniya (statisticheskiye materialy po SSSR) [Malignant neoplasms (statistical materials on the USSR)]. Moscow, Medicina, 1974. 188 p.

20. Petrova G.V., Kaprin A.D., Gretsova O.P., Starinskiy V.V. Zlokachestvennyye novoobrazovaniya v Rossii: obzor statisticheskoy informatsii za 1993-2013 gg. [Malignant neoplasms in Russia: review of statistical information for 1993-2013]. Moscow, FGBU MNIOI named after P.A. Gertsen, 2015. 511 p.

21. Lohi O., Jahnukainen K., Huttunen P., Taskinen M., Taskinen S., Pakarinen M., Koivusalo A., Rintala R., Kanerva J., Grönroos M., Heikinheimo M., Vettenranta K. Solid tumors in children. Duodecim, 2014, vol. 130, no. 20, pp. 2050-2059.

22. Sosnina S.F., Martinenko I.A., Fomin E.P., Vazhenin A.V. Analysis of cancer incidence of the population of the city of Ozersk for the period from 1948 to 2010. Health of population in industrial cities: Proc. interdis-ciplinary scientific-practical conference with international participation, Chelyabinsk, ABRIS, 2014, pp. 91-98. (In Russian).

23. Ivanov V.K., Drynova N.N., Vlasov O.K., Shchukina N.V., Efendiyev V.A. Delayed radiological conse-quences of the Chernobyl accident in population of the Bryansk oblast: solid cancers. Radiatsiya i risk – Radiation and Risk, 2008, vol. 17, no. 4, pp. 23-45. (In Russian).

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