Immune status of persons with CRS at later time points

«Radiation and Risk», 2018, vol. 27, no. 2, pp.76-85

DOI: 10.21870/0131-3878-2018-27-2-76-85

Authors

Akleyev A.A.^1,2 – Assoc. Prof., C. Sc., Med. South Ural State Medical University Ministry of Health RF, Urals Research Center for Radiation Medicine, FMBA of Ministry of Health RF, Chelyabinsk, Russia. Contacts: 64 Vorovsky str., Chelyabinsk, 454092, Russia. Tel.: +7 904-301-16-82; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Dolgushin I.I.¹ – Head of Dep., Member of RAS, Prof. South Ural State Medical University Ministry of Health RF, Chelyabinsk, Russia.

Abstract

The article presents analysis of the systemic immunity in people with chronic radiation syndrome (CRS) in 65 years after the onset of chronic radiation exposure. The main parameters of adaptive and innate immunity were studied in 61 Techa Riverside residents suffered from CRS in the 1950-1960s. Mean absorbed dose to red bone marrow (RBM), the critical organ for CRS development, which determined the syndrome clinical course, was 0.91±0.08 Gy, and maximum values reached 2.71 Gy. The comparison group was formed using the «copy-pair» method according to sex, age and dose to RBM. At later points the Techa Riverside residents with CRS demonstrated a decrease of absolute number of CD3+, CD4+, and CD8+ Т-cells in the peripheral blood as well as an increase of IL-4 and TNF-α levels in blood serum. The above mentioned changes testified about some suppression of a cellular component of immune system and cytokine imbalance. No cases of secondary immunodeficiency were diagnosed in people previously suffered from CRS. It can be assumed that the detected peculiarities of immunity can play a certain role in the development of late radiation effects.

Key words
Chronic radiation exposure, chronic radiation syndrome, Techa River, later time points, late radiation effects, radiobiological effects, red bone marrow, peripheral blood, innate immunity, adaptive immunity, cytokines.

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Full-text article (in Russian)