Synthesis of basic and applied research is the basis of obtaining high-quality findings and translating them into clinical practice

«Radiation and Risk», 2017, vol. 26, No. 2, pp.26-40

DOI: 10.21870/0131-3878-2017-26-2-26-40


Kaprin A.D.1 – General Director, Academician of RAS, MD, Prof. NMRRC.
Galkin V.N.2 – Director, MD, Prof. A. Tsyb MRRC.
Zhavoronkov L.P.2 – Deputy Director, MD. A. Tsyb MRRC.
Ivanov V.K.2 – Deputy Director, Chairman of RSCRP, Corresponding Member of RAS A. Tsyb MRRC.
Ivanov S.A.2 – Deputy Director, MD A. Tsyb MRRC.
Romanko Yu.S.2 – Head of Dep., MD, Prof. A. Tsyb MRRC. Contacts: 4 Korolev str., Obninsk, Kaluga region, Russia, 249036. Tel. (484) 399-30-88; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .


A. Tsyb Medical Radiological Research Centre, the branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation is the one of the largest and oldest radiological research institutions, which is capable to translate its own research findings of basic studies into clinical practice. Existence of Experimental, Clinical and Radiation-epidemiological research sectors allows the Center to solve a wide range of radiobiological problems and provide clinical researchers with new knowledge of cancer diseases and their treatment. With account of A. Tsyb MRRC capabilities the Ministry of Health gave the Center the research tasks of the nation-wide scale. The research was carried out in the following directions: development of novel nuclear medicine technology and optimization of radiation therapy for cancer; analysis of possibilities to modify radioresistance of tumor and normal tissues based on new knowledge of mechanisms of carcinogenesis; evaluation of attributable risks from chronic exposure to low-level radiation. The article presents the review of main findings of the studies implemented in 2015-2016. The results were published in 243 articles, 16 monographs, presented in Russian and International scientific forums, and protected by 16 patents.

Key words
Radiation medicine, radiation biology, radiation epidemiology, biomedical effects of ionizing radiation, radiation-induced risks, novel medical technologies, radiology, radiation therapy, nuclear medicine, cancer diseases, radiosensitivity, radioresistance.


1. Russian National Report. 30 years of the Chernobyl accident: results and prospects of overcoming its consequences in Russia, 1986-2016. Eds.: V.A. Puchkov, L.A. Bolshov. Moscow, EMERCOM of Russia, IBRAE RAS, 2016. 202 p. (In Russian).

2. Health effects of Chernobyl: prediction and actual data 30 years after the accident. Eds.: Corresponding Member of RAS V.K. Ivanov, Corresponding Member of RAS A.D. Kaprin. Moscow, GEOS, 2015. 450 p.(In Russian).

3. United Nations Scientific Committee on the Effects of Atomic Radiation Sources. Effects and risks of ionizing radiation. UNSCEAR 2016 Report to the General Assembly, with Scientific Annexes. New York, United Nations, 2017. 502 p.

Ivanov V., Kashcheev V., Chekin S., Maksioutov M., Tumanov K., Menyajlo A., Vlasov O., Kochergina E., Kashcheeva P., Shchukina N., Korelo A., Seleva N., Galkin V., Kaprin A., Saenko V., Yamashita S. Results of the thyroid cancer epidemiological survey in Russia following the Chernobyl accident. In: Thyroid Cancer and Nuclear Accidents. Long-Term Aftereffects of Chernobyl and Fukushima. Eds.: S. Yamashita, G. Thomas. Elsevier, 2017, pp. 87-95.

5. The Fukushima Daiichi Accident. Technical Volume 4/5: Radiological Consequences. Vienna, International Atomic Energy Agency, 2015. 245 p.

6. Kashcheev V.V., Meniailo A.N., Pryakhin E.A., Chekin S.Yu., Ivanov V.K. Assessment and comparison of cancer risks associated with medical and occupational exposure to radiation. Radiatsiya i risk – Radiation and Risk, 2015, vol. 24, no. 3, pp. 5-15. (In Russian).

7. Ivanov V.K., Kashcheev V.V., Chekin S.Yu., Menyaylo A.N., Pryakhin E.A., Tsyb A.F., Mettler F.A. Estimating the lifetime risk of cancer associated with multiple CT scans. J. Radiol. Prot., 2014, vol. 34, no. 4, pp. 825-841. doi: 10.1088/0952-4746/34/4/825.

8. Kashcheev V.V., Pryakhin E.A., Menyaylo A.N., Chekin S.Yu., Ivanov V.K. Comparing risk estimates following diagnostic CT radiation exposures employing different methodological approaches. Health Phys., 2014, vol. 106, no. 6, pp. 806-811. doi: 10.1097/HP.0000000000000096.

9. Ivanov V.K., Kashcheev V.V., Kashcheeva P.V., Chekin S.Yu., Menyajlo A.N., Pryakhin E.A., Balonov M.I., Golikov V.Yu., Zvonova I.A., Kalnitsky S.A., Bratilova A.A., Vodovatov A.V., Sarycheva S.S., Chipiga L.A., Shatsky I.G., Tyurin I.E., Lazebnaya G.V. Assessment of radiation risk in patients with X-ray radiological studies. Methodical recommendations MR Moscow, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2015. 34 p. (In Russian).

10. Ulyanenko S.E., Lychagin A.A., Koryakin S.N., Galkin V.N. The proton therapeutic facility with active scanning beam system Prometheus: radiological basics and perspectives. Issledovanija i praktika v medicine – Research'n Practical Medicine Journal, 2017, sp. issue 1, p. 107. (In Russian).

11. Solovev A.N., Fedorov V.V., Potetnya V.I., Nechaev V.V. Modeling peculiarities of hadronic interactions for solving the problems of radiation treatment using Geant4. Jelektronnoe modelirovanie – Electronic Simulation, 2015, vol. 37, no. 3, pp. 111-119. (In Russian).

12. Evstratova E.S., Kim J.-H., Kim Y.-K., Kim J.K., Petin V.G. Chemical inhibition of cell recovery after irradiation with sparsely and densely ionizing radiation. J. Radiat. Industry, 2016, vol. 10, no. 4, pp. 199-204.

13. Petriev V.M., Tishchenko V.K., Kurilchik A.A., Skvortsov V.G. Pharmacokinetic properties of new antitumor radiopharmaceutical on the basis of diamond nanoporous composites labeled with Rhenium-188. J. Phys.: Conf. Ser., 2017, vol. 784, no. 4, pp. 1-5.

14. Stepanenko V.F., Biryukov V.A., Karjakin O.B., Kaprin A.D., Galkin V.N., Ivanov S.A., Mardinskiy Yu.S., Kolyzhenkov T.V., Petukhov A.D., Bogacheva V.V., Akhmedova U.A., Yaskova E.K., Lepilina O.G., Sanin D.B., Skvortsov V.G., Ivannikov A.I., Khailov A.M., Anokhin Yu.N. Local absorbed doses of irradiation of medical personnel at brachytherapy of prostate cancer using 125I microsources of Russian production. Radiatsiya i risk – Radiation and Risk, 2017, vol. 26, no. 1, pp. 44-59. (In Russian).

15. Khvostunov I.K., Krylov V.V., Rodichev A.A., Shepel N.N., Korovchuk O.N. The biodosimetry assessment of whole body exposure after administration of iodine therapy to differentiated thyroid cancer patients. Radiatsiya i risk – Radiation and Risk, 2015, vol. 24, no. 4, pp. 62-73. (In Russian).

16. Kochetova T., Krylov V., Voloznev L., Bobrov R., Beloserova M., Spichencova O. 188Re-HEDP and 188Re-Zoledronic acid for palliative treatment of bone metastases. World J. Nucl. Med., 2016, vol. 15, suppl. 1, p. 22.

17. Kudryavtsev D.V., Kudryavtseva G.T., Gumenetskaya Yu.V., Davydov G.A., Starodubtsev A.L., Oleynik N.A., Dvinskikh N.Yu. Sentinel lymph node biopsy using the domestic diagnostic radiopharmaceutical 99mTc-Technephyt for treatment clinically localized cutaneous melanoma. Issledovanija i praktika v medicine – Research'n Practical Medicine Journal, 2017, sp. issue 1, p. 66. (In Russian).

18. Fomina E.S., Gumenetskaya Yu.V., Kudryavtseva G.T., Kudryavtsev D.V., Semin D.Yu. Complex treatment of cutaneous melanoma of head and neck. Proceedings of the Research and Practical Conference "Radiation and organism". Obninsk, 2016, pp. 126-127. (In Russian).

19. Strikanova I.A., Gumenetskaya Yu.V., Biryukov V.A., Obukhov A.A., Ivanova I.N., Makarova K.S. Distant radiation therapy in the mode of hypofractionation in prostate cancer. Proceedings of the Research and Practical Conference "Radiation and organism". Obninsk, 2016, pp. 113-125. (In Russian).

20. Gogolln D., Gulidov I., Ragulln Yu. Radiation therapy in the treatment of non-small-cell lung cancer. Vrach – The Doctor, 2016, no. 2, pp. 46-48. (In Russian).

21. Matchuk O.N., Zamulaeva I.A. A high radiation-induced level of heat shock proteins with a molecular mass of 27 and 70 KDA is a characteristic feature of sporadic sp cells in the MCF-7 breast cancer culture. Radiacionnaja biologija. Radiojekologija – Radiation Biology. Radioecology, 2016, vol. 56, no. 4, pp. 382-388. (In Russian).

22. Konoplyannikov A.G., Kalsina S.S., Lepehina L.A., Semenkova I.V., Agaeva E.V., Baboyan S.B., Rjumshina E.A., Nosachenko V.V., Alekseenskiy A.E., Zlotin S.G., Smirnov B.B., Konoplyannikov M.A. Detonation nanodiamond complexes with cancer stem cells inhibitors or paracrine products of mesenchymal stem cells as new potential medications. Kristallografija – Crystallography Reports, 2015, vol. 60, no. 5, pp. 831-836. (In Russian).

23. Krikunova L.I., Kiseleva V.I., Mkrtchjan L.S., Zamulaeva I.A. Molecular predictive factors in gynecologic cancers. Issledovanija i praktika v medicine – Research'n Practical Medicine Journal, 2015, sp. issue 1, p. 54. (In Russian).

24. Kulieva G.Z., Verbinskaya N.I., Rykova E.V., Krikunova L.I. Possibilities of brachytherapy for cervical cancer. Issledovanija i praktika v medicine – Research'n Practical Medicine Journal, 2017, sp. issue 1, p. 67.(In Russian).

25. Kurpeshev O.K., Florovskaya N.Yu., Lebedeva T.V. Results of palliative thermochemotherapy for colorectal cancer metastases to the liver. Voprosy onkologii – Problems in Oncology, 2016, vol. 62, no. 1, pp. 85-90. (In Russian).

26. Kaplan M.A., Galkin V.N., Romanko Yu.S., Osipchuk Yu.S., Drozhzhina V.V., Malova T.I., Ol'shevskaya V.A. Study of effectiveness of photodynamic therapy for PC-1 experimental tumors with a liposomal form of boronated derivative of chlorine e6 photosensitizer. Radiatsiya i risk – Radiation and Risk, 2016, vol. 25, no. 3, pp. 57-65. (In Russian).

27. Shikina E.S., Parshin V.S. Possibilities of compressive and shear wave elastography in differential diagnosis of benign nodules and papillary thyroid cancer. Diagnosticheskaja i intervencionnaja radiologija – Diagnostic and Interventional Radiology, 2016, vol. 10, no. 4, pp. 28-34. (In Russian).

28. Filimonova M.V., Yuzhakov V.V., Shevchenko L.I., Bandurko L.N., Sevankaeva L.E., Makarchuk V.M., Chesnakova E.A., Shevchuk A.S., Tsyganova M.G., Fomina N.K., Ingel I.E., Surinova V.I. Experimental study of antitumor activity of new nitric oxide synthase inhibitor T1023. Molekuljarnaja medicina – Molecular Medicine, 2015, no. 1, pp. 61-64. (In Russian).

29. Shkavrova T.G., Mihajlova G.F., Tsepenko V.V., Ryabikina N.V., Pavlov V.V. Asynchronous replication of TP53 and AURKA genes in patients with Hodgkin's lymphoma. Proceedings of the Research and Practical Conference "Radiation and organism". Obninsk, 2016, p. 139. (In Russian).

30. Malinova I.V., Yuzhakov V.V., Kiseleva M.V., Bandurko L.N., Komarova E.V., Ingel I.E., Sevankaeva L.E., Fomina N.K. The morphofunctional study of the viability of vitrified ovarian tissue (Proceedings of the I National Congress "Oncology of reproductive organs: from prevention and early detection to effective treatment", Moscow, 19-21 May 2016). Issledovanija i praktika v medicine – Research'n Practical Medicine Journal, 2016, sp. issue, p. 109. (In Russian).

31. Yuzhakov V.V., Kiseleva M.V., Malinova I.V., Bandurko L.N., Komarova E.V., Yakovleva N.D. The study of the vitrification effect on the functional morphology of ovarian tissue. Proceedings of the Research and Practical Conference "Radiation and organism". Obninsk, 2016, pp. 145-148.(In Russian).

Full-text article (in Russian)