Role of photodynamic therapy in the treatment of locally advanced lung cancer

«Radiation and Risk», 2015, vol. 24, No. 4, pp.53-61


Ragulin Yu.A.1 – Head of Dep., C. Sc., Med. A. Tsyb MRRC, Obninsk, Russia. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: +7 (484) 399-30-32; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Kaplan M.A.1 – Head of Dep., MD, Prof. A. Tsyb MRRC, Obninsk, Russia.
Kaprin A.D.1 – Director General, Corresponding Member of RAS, MD, Prof. NMRRC, Obninsk, Russia.
Galkin V.N.1 – Director, MD, Prof. A. Tsyb MRRC, Obninsk, Russia.
Kapinus V.N.1 – Physician, C. Sc. A. Tsyb MRRC, Obninsk, Russia.


The study was performed to evaluate efficacy of photodynamic therapy (PDT) and to examine the role of PDT combined with radiation therapy in the treatment of endobronchial lung cancer. Patients (93) with morphologically confirmed locally advanced non-small cell lung cancer who previously underwent conservative treatment at the clinics of MRRC were included in the study. All patients had obstructive ventilation disorders caused by tumor stenosis of the main bronchus or a lobar bronchus. Sixty three (63) patients received endoscopic PDT with chlorine photosensitizers. The study demonstrates high clinically efficacy and safety of this treatment modality. The use of photodynamic therapy prior to radiation therapy for patients with tumor stenosis of large bronchi has brought achievement of pronounced positive therapeutic effect due to elimination of atelectasis and hypoventilation. The results of study allow us to conclude, that inclusion of photodynamic therapy in the treatment schemes for inoperable lung cancer can improve outcome of conservative treatment and quality of life, as well as increase survival time.

Key words
lung cancer, photodynamic therapy, chlorine photosensitizers, radiation therapy, bronchoscopy, complications, tumor stenosis, ventilation disorders, survival time, quality of life.


1. Trahtenberg A.H., Chissov V.I. Rak legkogo: rukovodstvo, atlas [Lung Cancer: A Guide, atlas]. Moscow, GJeOTAR-Media, 2009. 656 p.

2. Abakushina E.V., Romanko Yu.S., Kaplan M.A., Kaprin A.D. Anticancer immune response and photody-namic therapy. Radiatsiya i risk – Radiation and Risk, 2014, vol. 23, no. 4, pp. 92-98. (In Russian).

3. Wieman T.J., Mang T.S., Fingar V.S., Hill T.G., Reed M.W., Corey T.S., Nguyen V.Q., Render E.R.Jr. Effects of photodynamic therapy on blood flow in normal and tumor vessels. Surgery, 1988, vol. 104, pp. 512-517.

4. Stranadko E.F. Istoricheskij ocherk razvitija fotodinamicheskoj terapii [History of PDT]. Lazernaya meditsina – Laser Medicine, 2002, vol. 6, no. 1, pp. 4-8. (In Russian).

5. Sokolov V.V., Telegina L.V., Pikin O.V., Trahtenberg A.H., Kaprin A.D. FDT pri rannem central'nom rake legkogo: klinicheskij opyt MNIOI im. P.A. Gercena MZ RF [PDT for early central lung cancer: clinical experi-ence of MNIOI P.A. Herzen]. Fotodinamicheskaja terapija i fotodiagnostika – Photodynamic Therapy and Fotodiagnosis, 2014, no. 1, pp. 34-35.

6. Banerjee A., George J. Bronchoscopic photodynamic diagnosis and therapy for lung cancer. Curr. Opin. Pulm. Med., 2000, vol. 6, pp. 378-383.

7. Spichenkova I.S., Kaplan М.A., Gulidov I.A., Sokol N.I., PonomarevН.V., Bandurko L.N. Combination of photodynamic therapy and rentgenotherapy in treatment of sarcoma M-l in rats. Rossiyskiy bioterapevticheskiy zhurnal – Russian Biotherapeutic Journal, 2005, no. 3, pp. 62-68. (In Russian).

8. Arseniev A.I., Kanayev S.V., Bartchuk A.S., VedeninYa.O., Klimenko V.N., Gelfond M.L., Shulepov A.V., Morozova O.A., Bartchuk A.A., Tarkov S.A. Use of endotracheobronchial surgery in conjunction with radiochemotherapy for advanced non-small lung cancer. Voprosy onkologii – Problems in Oncology, 2007, vol. 53, no. 4, pp. 461-467. (In Russian).

Full-text article (in Russian)