Follow-up methodology and analysis of mortality and cancer incidence in the cohort of people in utero exposed to radiation as a result of radioactive contamination of environment and the Techa River

«Radiation and Risk», 2015, vol. 24, No. 3, pp.92-104

Authors

Kharyuzov Yu.E. – Researcher. The Urals Research Center for Radiation Medicine, Chelyabinsk, Russia. Contacts: 68-a, Vorovsky Str., Chelyabinsk, Russia, 454076. Tel.: +7 (351) 232-79-14; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Krestinina L.Yu. – Head of Lab., C. Sc., Med. The Urals Research Center for Radiation Medicine, Chelyabinsk, Russia.
Tolstykh E.I. – Lead. Researcher, D. Sc., Biol. The Urals Research Center for Radiation Medicine, Chelyabinsk, Russia.
Akleyev A.V. – Director, MD, Prof. The Urals Research Center for Radiation Medicine, Chelyabinsk, Russia.

Abstract

A unique cohort of 11574 people in utero exposed to radiation as a result of technological radioac-tive contamination of environment and the Techa River was established. The period of follow-up is 60 years. The article presents the criteria for entry into the cohort, demographic description of the cohort and first results of analysis of solid cancer and leukemia incidence (242 and 15 cases re-spectively), mortality from these diseases (136 and 15 cases respectively) and from all causes (2359 cases). Individual radiation doses, including organ doses, received a cohort member in utero and from external and internal sources accumulated for the whole postnatal period were recon-structed with the dosimetry system developed at the Urals Research Center for Radiation Medicine. Average organ doses received in utero were 30 mGy to the red bone marrow and 4 mGy to soft tis-sues, average accumulated postnatal organ doses were 90mGy and 10 mGy to the red bone mar-row and soft tissues respectively. The cohort has potential for further study of cancer development in people in utero exposed to radiation.

Key words
In utero radiation exposure, the Techa River, risk of mortality, risk of incidence, solid malignant neoplasms, leukemias, environmental contamination, postnatal radiation exposure, co-hort studies, follow-up methodology.

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