RADIATION & RISK
Bulletin of the National Radiation and Epidemiological Registry
since 1992
About the Journal : 2015 : vol. 24, No. 1 : Application of photodynamic therapy for basal cell carcinoma using a local photosensitizer Photolon ОТОЗВАНА/RETRACTED 30.09.2019

Application of photodynamic therapy for basal cell carcinoma using a local photosensitizer Photolon ОТОЗВАНА/RETRACTED 30.09.2019

«Radiation and Risk», 2015, vol. 24, No. 1, pp.108-117

Authors

Molochkov A.V.1 – Deputy Director, MD, Prof., M.F. Vladimirskiy MRRCI, Moscow.
Kaprin A.D.2 – Director General, Corresponding Member of RAS, MD, Prof., NMRRC, Moscow.
Galkin V.N.3 – Director, MD, Prof., A. Tsyb MRRC, Obninsk.
Molochkov V.A. – Head of Dep., MD, Prof., M.F. Vladimirskiy MRRCI, Moscow.
Kaplan M.A.3 – Head of Dep., MD, Prof., A. Tsyb MRRC, Obninsk.
Suhova T.E.1 – Head of Dep., MD, M.F. Vladimirskiy MRRCI. Contacts: 61/2 Shepkina St., Moscow, Russia, 129110. Tel.: +74956819889; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Ivanov S.A.3 – Deputy Director, MD. A. Tsyb MRRC, Obninsk
Romanko Yu.S.3 – Head of Dep., MD, Prof. A. Tsyb MRRC, Obninsk
Popuchiev V.V.3 – Lead. Researcher, MDA. Tsyb MRRC, Obninsk
Epatova T.V.3 – Senior Researcher. A. Tsyb MRRC, Obninsk.

Abstract

The Department of Dermatology and Venereology and Dermatooncology of M.F. Vladimirskiy MRRCI and the Department of Photodynamic diagnosis and therapy of A. Tsyb MRRC developed a new technique of photodynamic therapy for basal cell carcinoma with local application of chlorine series Photolon. Photodynamic therapy with the local use of this drug has shown to be highly effective in the treatment of all clinical forms of the disease. Photodynamic therapy techniques basal cell carcinoma using local and intravenous photosensitizer comparable with each other. Our results have shown that photodynamic therapy using a photosensitizer local has significant advantages. The method is inexpensive and effective treatment with good cosmetic result, does not require compliance with the light regime, has no side effects and complications, can be used without restriction of age and the presence of comorbidities, the treatment of choice in patients with severe somatic pathology in patients older age group, can be used for disease recurrence repeated many times. PDT is preferably carried out in an outpatient setting.

Key words
photodynamic therapy, oncology, dermatology, skin diseases, skin tumors, basal cell carcinoma, a photosensitizer, laser radiation, intralesional administration of a photosensitizer, the local administration of a photosensitizer.

References

1. Molochkov V.A., Snarskaya E.S., Polyakov P.Yu., Afonin A.V., Sukhova T.E., Romanko Yu.S., Khlebnikova A.N., Taranets T.A., Koroleva L.P., Kladova A.Yu., Chelyukanova M.V., Kozlova E.S. K probleme lecheniya bazaliom kozhi [To the treatment of skin basaliomas]. Rossijskij zhurnal kozhnyh i venericheskih boleznej – Russian Journal of Skin and Sexually Transmitted Diseases, 2005, no. 6, pp. 4-9.

2. Sukhova T.E., Molochkov V.A., Romanko Yu.S., Matveeva O.V., Reshetnikov A.V. Lechenie bazal'nokletochnogo raka kozhi na sovremennom etape [The present day therapy of cutaneous basal cell carcinoma]. Al'manah klinicheskoj mediciny – Digest of Clinical Medicine, 2008, no. 18, pp. 14-21.

3. Romanko Yu.S., Kaplan M.A., Popuchiev V.V., Molochkov V.A., Sukhova T.E., Tret'yakova B.I., Taranets T.A. Bazal'no-kletochnyy rak kozhi: problemy lecheniya i sovremennye aspekty fotodinamicheskoy terapii [Basal cell carcinoma of the skin: the problems of treatment and the current aspects of photodynamic therapy]. Rossijskij zhurnal kozhnyh i venericheskih boleznej – Russian Journal of Skin and Sexually Transmitted Diseases, 2004, no. 6, pp. 6-10.

4. Filonenko E.V. Fizicheskie metody v lechenii bol'nykh rakom kozhi [Physical methods in the treatment of skin cancer patients]. Medicinskie tehnologii. Ocenka i vybor – Medical Technologies. Evaluation and Selection, 2012, no. 2(8), pp. 100-105.

5. Molochkov A.V., Romanko Yu.S., Kazantseva K.V., Sukhova T.E., Popuchiev V.V., Tret'yakova E.I., Matveeva O.V., Kuntsevich Zh.S., Molochkova Yu.V., Prokof'ev A.A., Dibirova S.D. Lazeroindutsirovannaya termoterapiya i fotodinamicheskaya terapiya v dermatologii: vozmozhnosti i perspektivy [Laser-induced thermotherapy and photodynamic therapy in dermatology: opportunities and future horizons]. Al'manah klinicheskoj mediciny – Digest of Clinical Medicine, 2014, no. 34, pp. 30-35.

6. Kaplan M.A., Romanko Yu.S. Lazernaya fotodinamicheskaya terapiya (obzor, sostoyanie problemy i perspektivy) [Laser photodynamic therapy]. Fizioterapija, bal'neologija i reabilitacija – Physiotherapy, Balneology and Rehabilitation, 2004, no. 1, pp. 43-48.

7. Kaplan M.A., Nikitina R.G., Romanko Yu.S., Bozadzhiev L.L., Malygina A.I., Drozhzhina V.V. Fotodinamicheskaya terapiya sarkomy M-1 u eksperimental'nykh zhivotnykh [Photodynamic therapy for carcinoma M-1 in experimental animals]. Lazernaja medicina – Laser Medicine, 1998, vol. 2, no. 2-3, pp. 38-42.

8. Kaplan M.A., Ponomarev G.V., Baum R.F., Romanko Yu.S., Mardynskaya V.P., Malygina A.I. Izuchenie spetsificheskoy fotodinamicheskoy aktivnosti fotoditazina pri fotodinamicheskoy terapii sarkomy M-1 u krys[Izuchenie spetsificheskoy fotodinamicheskoy aktivnosti fotoditazina pri fotodinamicheskoy terapii sarkomy M-1 u krys]. Rossijskij bioterapevticheskij zhurnal – Russian Journal of Biotherapeutic, 2003, vol. 2, no. 4, pp. 23-30.

9. Romanko Yu.S. Fotodinamicheskaya terapiya bazal'nokletochnogo raka kozhi (eksperimental'no-klinicheskoe issledovanie). Diss. dokt. med. nauk [Photodynamic therapy basal cell skin cancer (experimentally-clinical research). Dr. med. sci. diss.]. Obninsk, 2005.

10. Volgin V.N., Stranadko E.F., Trishkina O.V., Kabanova M.A., Kagoyants R.V. Sravnitel'naya kharakteristika razlichnykh vidov lecheniya bazal'no-kletochnogo raka kozhi [Comparative characteristics of therapies for cutaneous basal-cell carcinoma]. Rossijskij zhurnal kozhnyh i venericheskih boleznej – Russian Journal of Skin and Sexually Transmitted Diseases, 2013, no. 5, pp. 4-10.

11. Taranets T.A., Sukhova T.E., Romanko Yu.S. Fotodinamicheskaya terapiya bazal'no-kletochnogo raka kozhi s lokal'nym i vnutrivennym ispol'zovaniem fotosensibilizatora khlorinovogo ryada «Fotolon» [Photodynamic therapy basal cell skin cancer with local and intravenous use chlorine series «Photolon»]. Al'manah klinicheskoj mediciny – Digest of Clinical Medicine, 2007, no. 15, pp. 283-288.

12. Sukhova T.E., Romanko Yu.S., Matveeva O.V. Fotodinamicheskaya terapiya bazal'no-kletochnogo raka kozhi s lokal'nym primeneniem radakhlorina [Photodynamic therapy for basal-cell carcinoma with the local application of radachlorine]. Rossijskij zhurnal kozhnyh i venericheskih boleznej – Russian Journal of Skin and Sexually Transmitted Diseases, 2008, no. 4, pp. 41-44.

13. Sukhova T.E., Romanko Yu.S., Yaroslavtseva-Isaeva E.V., Korenev S.V., Prokof'ev A.A. Vnutritkanevoy variant vvedeniya fotosensibilizatora pri fotodinamicheskoy terapii bazal'no-kletochnogo raka kozhi (soobshchenie 1) [Interstitial options for introducing of a photosensitizer in photodynamic therapy of basal cell skin cancer (report 1)]. Rossijskij zhurnal kozhnyh i venericheskih boleznej – Russian Journal of Skin and Sexually Transmitted Diseases, 2010, no. 2, pp. 4-10.

14. Molochkov A.V., Sukhova T.E., Tret'yakova E.I., Akopova K.V., Koroleva L.P., Prokof'ev A.A., Rumyantsev S.A., Alieva P.M., Romanko Yu.S., Molochkov V.A. Sravnitel'nye rezul'taty effektivnostilazeroindutsirovannoy termoterapii i fotodinamicheskoy terapii poverkhnostnoy i mikronodulyarnoy bazaliom [Comparative evaluation of the efficiency of laser-induced and photodynamic therapy for surface and micronodular basaloma]. Rossijskij zhurnal kozhnyh i venericheskih boleznej – Russian Journal of Skin and Sexually Transmitted Diseases, 2012, no. 4, pp. 30-36.

15. Sukhova T.E., Molochkov V.A., Romanko Yu.S., Changlyan K.A., Tret'yakova E.I. Fotodinamicheskaya terapiya aktinicheskogo keratoza s applikatsionnym primeneniem «Fotoditazina» [Photodynamic therapy of actinic keratoses with applicator using «Photoditazin»]. Rossijskij zhurnal kozhnyh i venericheskih boleznej – Russian Journal of Skin and Sexually Transmitted Diseases, 2010, no. 5, pp. 4-8.

16. Kazantseva K.V., Molochkov A.V., Molochkov V.A., Sukhova T.E., Prokof'ev A.A., Kaprin A.D., Galkin V.N., Ivanov S.A., Kaplan M.A., Romanko Yu.S., Popuchiev V.V. Sarkoma Kaposhi: patogenez, klinika, diagnostika i sovremennye printsipy lecheniya [Kaposi's sarcoma: pathogenesis, clinical features, diagnosis and modern principles of treatment ]. Rossijskij zhurnal kozhnyh i venericheskih boleznej – Russian Journal of Skin and Sexually Transmitted Diseases, 2015, vol. 18, no. 1, pp. 7-15.

17. Kaplan M.A., Romanko Yu.S., Popuchiev V.V., Kapinus V.N. Atlas fotodinamicheskoy terapii [Atlas photodynamic therapy]. Moscow, Littera, 2015. 320 p.

18. Romanko Yu.S., Korenev S.V., Popuchiev V.V., Vaysbeyn I.Z., Sukhova T.E. Osnovy fotodinamicheskoy terapii [Basics of photodynamic therapy]. Kaliningrad, 2010. 136 p.

19. Romanko Yu.S., Tsyb A.F., Kaplan M.Aa., Popuchiev V.V. Vliyanie fotodinamicheskoy terapii s Fotoditazinom na morfofunktsional'nye kharakteristiki sarkomy M-1 [Effect of photodynamic therapy with photodithazine on morphofunctional parameters of M-1 sarcoma]. Byulleten' eksperimental'noy biologii i meditsiny – Bulletin of Experimental Biology and Medicine, 2004, vol. 138, no. 6, pp. 584-589.

20. Romanko Yu.S., Tsyb A.F., Kaplan M.A., Popuchiev V.V. Zavisimost' protivoopukholevoy effektivnosti fotodinamicheskoy terapii ot plotnosti svetovoy energii [Relationship between antitumor efficiency of photo-dynamic therapy with photoditasine and photoenergy density]. Byulleten' eksperimental'noy biologii i meditsiny – Bulletin of Experimental Biology and Medicine, 2005, vol. 139, no. 4, pp. 460-464.

Full-text article (in Russian)