RADIATION & RISK
Bulletin of the National Radiation and Epidemiological Registry
since 1992
About the Journal : 2014 : vol. 23, No. 2 : Differentiated approach to the use of adjuvant radiation therapy for patients with operable breast cancer

Differentiated approach to the use of adjuvant radiation therapy for patients with operable breast cancer

«Radiation and Risk», 2014, vol. 23, No. 2, pp.102-111

Authors

Startseva Zh.A. – Division Head, MD, Tomsk Cancer Research Institute, Russian Academy of Medical Sciences, Tomsk.
Simonov K.A. – Oncologist, Tomsk Cancer Research Institute, Russian Academy of Medical Sciences, Tomsk. Contacts: 5 per. Kooperativnyi, Tomsk, Russia, 634009. Tel.: 8 (3822) 42-00-62; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Slonimskaya E.M. – Division Head, MD, Prof., Tomsk Cancer Research Institute, Russian Academy of Medical Sciences, Tomsk.

Abstract

The authors discuss the problem of choice of optimal radiation treatment volume of breast cancer with account of meaningful morphological factors. Patients (196) with operable breast cancer T1-3N0-3M0 were given complex treatment: chemotherapy, radical treatment with neo- and adjuvant chemotherapy, radical mastectomy and postoperative external beam radiation therapy for different radiation treatment volumes. Using single-factor statistical analysis we estimated retrospectively 5-year disease-free survival rates in relation to a radiation treatment volume and major morphological prognostic factors of the disease. Prognostic models describing probability of local recurrences of breast cancer were developed for individualization of radiation therapy tactics. Taking into account risk factors for local tumor progression allows a physician to individualize indications for radiation therapy, thereby reducing unjustified radiation dose without deterioration of delayed treatment outcomes.

Key words
Radiation therapy, breast cancer, radical mastectomy, differentiated approach, single-factor analysis, clinico-morphological factors, radiation treatment volume.

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