RADIATION & RISK
Bulletin of the National Radiation and Epidemiological Registry
since 1992
About the Journal : 2014 : vol. 23, No. 1 : Solid cancer incidence among emergency workers of the Chernobyl accident: assessment of radiation risks for the follow-up period of 1992-2009

Solid cancer incidence among emergency workers of the Chernobyl accident: assessment of radiation risks for the follow-up period of 1992-2009

«Radiation and Risk», 2014, vol. 23, No. 1, pp.19-31

Authors

Kashcheev V.V. – Senior Researcher, C. Sc., Biol.,Medical Radiological Research Center of the Russian Ministry of Health, Obninsk. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: (48439) 9-32-81; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Chekin S.Yu. – Senior Researcher,Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Maksioutov M.A. – Head of Lab., C. Sc., Tech.,Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Tumanov K.A. – Senior Researcher, C. Sc., Biol.,Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Kochergina E.V. – Head of Lab., C. Sc., Med.,Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Shchukina N.V. – Research Assistant,Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Ivanov V.K. – Chairman of RSCRP, Deputy Director, Corresponding Member of RAMS,Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.

Abstract

The cancer among emergency workers of the Chernobyl accident for the follow-up period of 1992–2009 is analyzed in the article. The cohort consists of 67,568 emergency workers of 1986–1987. Mean dose in emergency workers is 132 mGy. Over the period of 1992-2009 a total of 4,002 solid cancers of different sites were diagnosed in the study cohort. The statistically significant increase by 18% in the incidence rates for all solid cancers in the emergency workers was detected in comparison with the background incidence in the male population of Russia (SIR=1.18, 95% CI: 1.15; 1.22). As for the malignant neoplasms of respiratory system, the average incidence rate was 27%, it is significantly higher than in men of Russia (SIR=1.27, 95% CI: 1.19; 1.34). Radiation risk for cancer incidence [excess relative risk per unit dose 1 Gy (ERR Gy-1) is 0.47; 95% confidence interval (CI): 0.03; 0.96, p–value=0.034)] is found to be statistically significant. The obtained results are preliminary, further epidemiological studies are necessary.

Key words
Emergency workers, cancer morbidity, radiation risks, attributable risk.

References

1. Zlokachestvennye novoobrazovaniia v Rossii v 1992-2009 gg. (zabolevaemost' i smertnost'): spravochnik [ ] pod red. akad. RAMN V.I.Chissova, prof. V.V.Starinskogo. Moscow., 1993-2010.

2. Ivanov V.K., Kashcheev V.V., Chekin S.Iu., Maksiutov M.A., Tumanov K.A., Kochergina E.V., Shchukina N.V., Tsyb A.F. Zabolevaemost' i smertnost' uchastnikov likvidatsii posledstvii avarii na Chernobyl'skoi AES: otsenka radiatsionnykh riskov, period nabliudeniia 1992-2008 gg. [ ] Radiatsionnaia gigiena. 2011. Vol. 4, No 2. pp. 40-49.

3. Ivanov V.K., Tsyb A.F., Gorskii A.I., Maksiutov M.A., Chekin S.Iu., Petrov A.V., Tumanov K.A., Kashcheev V.V. Onkozabolevaemost' i onkosmertnost' sredi uchastnikov likvidatsii posledstvii avarii na ChAES: otsenka radiatsionnykh riskov [ ] Radiatsionnaia biologiia. Radioekologiia. 2006. Vol. 46, No 2. pp. 159-166.

4. Ivanov V.K., Tsyb A.F., Ivanov S.I. Likvidatory chernobyl'skoi katastrofy: radiatsionno-epidemiologicheskii analiz meditsinskikh posledstvii. Moscow, Galanis, 1999. 312 p.

5. Ivanov V.K., Chekin S.Iu., Kashcheev V.V., Maksiutov M.A., Tsyb A.F. Smertnost' likvidatorov posledstvii avarii na Chernobyl'skoi AES: analiz dozovoi zavisimosti (kogortnye issledovaniia, 1992-2006) [ ] Radiatsiia i risk. 2007. Vol. 16, No. 2-4. pp. 15-26.

6. Cardis E., Anspaugh L., Ivanov V.K., Likhtarev L.A., Mabuchi K., Okeanov A.E., Prisyazjhniuk A.E. Estimated long term health effects of the Chernobyl accident Proceedings of an IAEA Conference One Decade after Chernobyl: Summing up the Consequences of the Accident, Vienna, 8-12 April 1996. Vienna, 1996. pp. 241-271.

7. Chumak V.V., Romanenko A.Y., Voillequé P.G., Bakhanova E.V., Gudzenko N., Hatch M., Zablotska L.B., Golovanov I.A., Luckyanov N.K., Sholom S.V., Kryuchkov V.P., Bouville A. The Ukrainian-American study of leukemia and related disorders among Chornobyl cleanup workers from Ukraine: II. Estimation of bone marrow doses /Radiation Research. 2008. V. 170, No. 6. pp. 698-710.

8. Howe G.R. Leukemia following the Chernobyl accident Health Physics. 2007. V. 93, No. 5. pp. 512-515.

9. Ivanov V.K. Late cancer and noncancer risks among Chernobyl emergency workers of Russia [ ]Health Physics. 2007. Vol. 93, No. 5. pp. 470-479.

10. Ivanov V.K., Chekin S.Yu., Kashcheev V.V., Maksioutov M.A., Tumanov K.A. Risk of thyroid cancer among Chernobyl emergency workers of Russia Radiat. Environ. Biophys. 2008. Vol. 47, No. 4. pp. 463-467.

11. Ivanov V.K., Gorsky A.I., Kashcheev V.V., Maksioutov M.A., Tumanov K.A. Latent period in induction of radiogenic solid tumors in the cohort of emergency workers Radiat. Environ. Biophys. 2009. Vol. 48, No. 3. pp. 247-252.

12. Ivanov V.K., Kashcheev V.V., Chekin S.Yu., Maksioutov M.A., Tumanov K.A., Vlasov O.K., Shchukina N.V., Tsyb A.F. Radiation-epidemiological studies of thyroid cancer incidence in Russia after the Chernobyl accident (estimation of radiation risks, 1991-2008 follow-up period) Radiat. Prot. Dosimetry. 2012. Vol. 151, No. 3. pp. 489-499.

13. Ivanov V.K., Tsyb A.F., Ivanov S.I., Pokrovsky V.I. Medical radiological consequences of the Chernobyl catastrophe in Russia: estimation of radiation risks. St. Petersburg: Nauka, 2004. 388 p.

14. Ivanov V.K., Tsyb A.F., Konogorov A.P., Rastopchin E.M., Khait S.E. Case-control analysis of leukaemia among Chernobyl accident emergency workers residing in the Russian Federation, 1986-1993 J. Radiol. Prot. 1997. Vol. 17, No. 3. pp. 137-157.

15. Kesminiene A., Cardis E., Tenet V., Ivanov V.K., Kurtinaitis J., Malakhova I., Stengrevics A., Tekkel M. Studies of cancer risk among Chernobyl liquidators: materials and methods J. Radiol. Prot. 2002. Vol. 22,

No. 3A. pp. A137-A141.
16. Kesminiene A., Evrard A.-S., Ivanov V.K., Malakhova I.V., Kurtinaitis J., Stengrevics A., Tekkel M., Anspaugh L.R., Bouville A., Chekin S., Chumak V.V., Drozdovitch V., Gapanovich V., Golovanov I., Hubert P., Illichev S.V., Khait S.E., Kryuchkov V.P., Maceika E., Maksyoutov M., Mirkhaidarov A.K., Polyakov S., Shchukina N., Tenet V., Tserakhovich T.I., Tsykalo A., Tukov A.R., Cardis E. Risk of hematological malignancies among Chernobyl liquidators Radiation Research. 2008. Vol. 170, No. 6. pp. 721-735.

17. Konogorov A.P., Ivanov V.K., Chekin S.Yu., Khait S.E. A case-control analysis of leukemia in accident emergency workers of Chernobyl J. Environ. Pathol. Toxicol. Oncol. 2000. Vol. 19, No. 1-2. pp. 143-151.

18. Pitkevich V.A., Duba V.V., Ivanov V.K., Chekin S.Yu., Tysb A.F., Vakulovsky S.M., Shershakov V.M., Makhon'ko K.P., Golubenkov A.V., Borodin R.V., Kosykh V.S. Reconstruction of composition of the Chernobyl radionuclide fallout and external radiation absorbed doses of population in the areas of Russia Radiat. Prot. Dosimetry. 1996. Vol. 64, No. 1-2. pp. 69-92.

19. Preston D.L., Lubin J.H., Pierce D.A., McConney M.E. EPICURE User's Guide. Seattle: Hirosoft International Corporation, 1993. 330 р.

20. Preston D.L., Ron E., Tokuoka S., Funamoto S., Nishi N., Soda M., Mabuchi K., Kodama K. Solid cancer incidence in atomic bomb survivors: 1958-1999 Radiat. Res. 2007. Vol. 168, No. 1. pp. 1-64.

21. Rahu M., Rahu K., Auvinen A., Tekkel M., Stengrevics A., Hakulinen T., Boice J.D.Jr.,Inskip P.D. Cancer risk among Chernobyl cleanup workers in Estonia and Latvia, 1986-1998 Int. J. Cancer. 2006. Vol. 119, No. 1. pp. 162-168.

22. Romanenko A., Bebeshko V., Hatch M., Bazyka D., Finch S., Dyagil I., Reiss R., Chumak V., Bouville A., Gudzenko N., Zablotska L., Pilinskaya M., Lyubarets T., Bakhanova E., Babkina N., Trotsiuk N., Ledoschuk B., Belayev Y., Dybsky S.S., Ron E., Howe G. The Ukrainian-American Study of Leukemia and Related Disorders among Chornobyl Cleanup Workers from Ukraine: I. Study Methods Radiation Research. 2008. Vol. 170, No. 6. pp. 691-697.

Full-text article (in Russian)