RADIATION & RISK
Bulletin of the National Radiation and Epidemiological Registry
since 1992
About the Journal : 2012 : vol. 21, No. 4 : Radiation and spermatogenesis: experimental estimation of radiation effect at doses below castrate level on ontogenesis

Radiation and spermatogenesis: experimental estimation of radiation effect at doses below castrate level on ontogenesis

«Radiation and Risk», 2012, vol. 21, no. 4, pp.51-60

Authors

Dergilev A.A. – Postgraduate Student, Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Palyga G.F. – Main Researcher, MD. Prof., Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Chibisova O.F. – Researcher, Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Ivanov V.L. –- Senior Researcher, C. Sc., Vet., Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Panfiliva V.V. – Postgraduate Student, Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Zhavoronkov L.P. – Head of Dep., MD, Medical Radiological Research Center of the Russian Ministry of Health, Obninsk. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: (48439) 9-71-38; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .

Abstract

Authors investigated reproductive function of Wistar females, antenatal and postnatal development of two generations offspring of Wistar males with germ cells irradiated at doses below the castrate level (0.5; 1.0 or 1.5 Gy; dose rate 0.003 Gy/sec) in all stages of spermatogenesis. Radiation produced negative effect on reproductive function of intact females, antenatal and postnatal development of the first generation offspring of males with germ cells irradiated at postmeiosis. Less, however evident radiation associated abnormal embryonic and postnatal development was observed in the second generation offspring of irradiated Wistar, this indicates genome instability.

Key words
Wistar rats, males, gamma irradiation, spermatogenesis, posterity.

References

1. Dergilev A.A., Chibisova O.F., Palyga G.F. et al. Influence of ionizing radiation in non-sterilizing doses on embryogenesis and postnatal development of the offspring of two generations of male rats whose sex cells are irradiated in premeotic stages of spermatogenesis. Radiation and Risk. 2012. Vol. 21, No. 2. PP. 39-45.

2. Palyga G.F., Zakoschikov K.F., Epatova Т.V. Influence of total gamma irradiation of females on pregnancy and postnatal development of offspring // Archive of anatomy, histology and embryology. 1984. Vol. LXXXVII, No. 12. PP. 71-76.

3. Palyga G.F., Chibisova OF, Ivanov V.L. and others. The implementation of radiation effects in ontogeny of the offspring of two generations of males whose sexual cells are irradiated once in non-sterilizing doses at the stage of mature spermatozoa. Radiation and Risk. 2010. Vol. 19, No. 4. PP. 58-62.

4. Palyga G.F., Chibisova OF, Ivanov V.L. and others. The implementation of radiation effects in ontogeny of the offspring of two generations of males whose sex cells are irradiated once in non-sterilizing doses at the stage of spermatids. Radiation and Risk. 2011. Vol. 20, No. 1. PP. 19-23.

5. Russell V.L. Genetic effect of ionizing radiation in mammals. Radiobiology. Selected chapters. Ed. A. Hollender. M. 1960. PP. 11-56.

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