Effect of peptides on postradiation recovery of hemopoiesis

«Radiation and Risk», 2012, vol. 21, no. 4, pp.42-50


Goryacheva A.S.1 – Postgraduate Student, Medical Radiological Research Center of the Russian Ministry of Health, Obninsk. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: (48439) 9-71-38; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Luzyanina A.A.1 – Researcher, Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Izmestieva O.S.1 – Lead. Researcher, C. Sc., Biol., Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Zhavoronkov L.P.1 – Head of Lab., D. Sc., Biol., Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Saenko A.S.1 – Deputy Director, D. Sc., Biol., Prof., Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Deigin V.I.2 – D. Sc., Biol., Prof., M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow.


In the work we investigated the possibility of reducing the harmful effects of ionizing radiation on the hematopoietic system of mice with linear and cyclic peptides of low molecular weight. The results showed that after double intraperitoneal injections of the peptides to irradiated mice (4 Gy) practically complete regeneration of cellularity of bone marrow and spleen observed on the eighth day. Signs of accelerated hematopoietic regeneration in the peripheral blood (reticulocytosis) were also observed. The positive effect of the peptides by criteria of cellularity of the bone marrow and spleen was seen in animals got higher dose (6 Gy), however, it was poorer, as compared with the effect observed in mice with dose of 4 Gy.

Key words
Hemopoiesis, peptides, ionizing radiation, mice.


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