RADIATION & RISK
Bulletin of the National Radiation and Epidemiological Registry
since 1992
About the Journal : 2012 : vol. 21, No. 3 : Section 3. Scientific Articles : Dependence of simultaneous exposure of gamma-rays and neutrons with energy 14 MeV effectiveness on high-LET component contribution

Dependence of simultaneous exposure of gamma-rays and neutrons with energy 14 MeV effectiveness on high-LET component contribution

«Radiation and Risk», 2012, vol. 21, no. 3, pp.82-90

Authors

Beketov E.E. – Researcher, Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Isaeva E.V. – Senior Researcher, C. Sc., Biol.,Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Koryakin S.N. – Leading Researcher, C. Sc., Biol., Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Lychagin A.A. – Head of Lab., C. Sc., Phys.-Math.,Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Ulyanenko S.E. – Head of Dep., D. Sc., Biol., Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: (48439) 9-72-10; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .

Abstract

Biological action of simultaneous irradiation by neutrons with energy 14 MeV and 60Co gamma-rays with different high-LET component contribution to the total dose have been studied. Compact generator ING-031 (3Н(d,n)4Не) was used as neutron source. Irradiation efficacy was estimated with melanoma B-16 clonogenic assay. It is shown that simultaneous exposure of neutrons and photons is more effective in case of 30 % neutron contribution. At 15 and 3 % values of this parameter cell survival was lower than theoretical values calculated in accordance with independent action of these radiations – synergism was observed. Neutron contribution increase to 45 % resulted in decrease of the effect to additivity.

Key words
Neutrons 14 MeV, melanoma B-16, mixed radiation, synergism.

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