The impact of pre-operative radiotherapy on the results of treatment and the risk of the development of the second tumors in patients with undifferentiated carcinoma of the stomach

«Radiation and Risk», 2012, vol. 21, no. 3, pp.75-81


Davtyan A.G. – Postgraduate Student, Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Skoropad V.Yu. – Lead. Researcher, MD, Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk. Contacts: 4 Korolyovstr., Obninsk, Kaluga region, Russia, 249036. Tel.: (48439) 9-31-65, fax: (495) 956-14-40,e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Berdov B.A. – Deputy Director, Head of Dep., MD, Prof., Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Titova L.N. – Physician, C. Sc., Med., Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.


The paper analyses the results of the combined and surgical treatment of patients with undifferentiated carcinoma of the stomach. It is shown that the intensive courses of preoperative irradiation well tolerated by patients. Despite the small interval of time from the completion of the radiation before surgery, therapeutic pathomorphosis of 2-3 degree takes place in half of the patients. Preoperative radiation therapy does not lead to an increase in the frequency and severity of postoperative complications, does not increase the rate of postoperative mortality. Surgical treatment of undifferentiated carcinoma of the stomach, except for the early stages, is inefficient. The use of preoperative radiation therapy statistically significantly improves the long-term results of treatment. The frequency of metachronous malignant neoplasms after the combined and surgical treatment is not different.

Key words
Undifferentiated carcinoma of the stomach, preoperative radiotherapy, multimodal treatment, surgical treatment, metachronous malignant neoplasms.


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