Polymorphism of the gene HFE is a risk factor for endometrial cancer in women of reproductive age

«Radiation and Risk», 2012, vol. 21, no. 2, pp.54-60

Authors

Ivanova T.I. – Leading Researcher, C. Sc., Biol.,Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: (48439) 9-71-64; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Krikunova L.I. – Head of Dep., MD, Prof., Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Khorokhorina V.A. – Senior Researcher, C. Sc., Biol.,Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Verbinskaya N.I. – Radiologist, C. Sc., Med., Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Mkrtchyan L.C. – Senior Researcher, C. Sc., Med., Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Ryabchenko N.I. – Head of Dep., D. Sc., Biol., Prof., Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Zamulaeva I.A. – Head of Lab., D. Sc., Biol., Prof.,Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Tsyb A.F. – Director, Academician of RAMS,Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.

Abstract

The association between polymorphisms in the HFE gene (homozygous and heterozygous for minor alleles 187G и 845A) and endometrial cancer risk is analyzed in 236 cases (160 endometrial cancer + 76 endometrial hyperplasia) and 112 healthy women. Genotyping was performed with PCR/RFLP assay (the PCR products are digested using appropriate restriction endonucleases and the resulting restriction fragments are separated according to their lengths by gel electrophoresis). A significant difference was observed in frequencies of polymorphic HFE alleles between the women of reproductive age and the elderly subjects (р=0,0005). The endometrial cancer risk increased for women of reproductive age with a minor alleles 187G or 845A HFE gene.

Key words
Рolymorphism, gene, alleles, endometrial cancer.

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