RADIATION & RISK
Bulletin of the National Radiation and Epidemiological Registry
since 1992
About the Journal : 2012 : vol. 21, No. 2 : Effect of exposure of rat male germ cells in the pre-meiotic phase of spermatogenesis to radiation at doses below a castration level on ontogenesis of two generations of posterity

Effect of exposure of rat male germ cells in the pre-meiotic phase of spermatogenesis to radiation at doses below a castration level on ontogenesis of two generations of posterity

«Radiation and Risk», 2012, vol. 21, no. 2, pp.39-45

Authors

Dergilev A.A. – Postgraduate Student,Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Chibisova O.F. – Research Assistant,Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Palyga G.F. – Main Researcher, MD, Prof.,Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Ivanov V.L. – Senior Researcher, C. Sc., Vet., Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Zhavoronkov L.P. – Head of Dep., MD,Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: (48439) 9-71-38; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .

Abstract

To study radiation effect on ontogenesis of two generations of a posterity, Wistar rats male germ cells in the pre-meiotic phase of spermatogenesis were irradiated with 60Co  at  doses  below  a  castration  level  (0.5; 1.0  or  1.5  Gy;  dose rate 0,003 Gy/sec). The rat males with irradiated germ cells were coupled with intact females. The marked radiation effect on the development of a posterity at antenatal and early postnatal periods was observed in the first generation. Radiation associated abnormalities of the development of the second generation were registered as tendency. Conclusion: negative effect of irradiation of rat male germ cells in the pre-meiotic phase is less evident than the effect on spermatozoa and spermatids.

Key words
Wistar male rats, gamma-irradiation of spermatocytes and spermatogonia, posterity.

References

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