RADIATION & RISK
Bulletin of the National Radiation and Epidemiological Registry
since 1992
About the Journal : 2012 : vol. 21, No. 1 : Monitoring of the frequency of lymphocytes with mutations at T-cell receptor locus in Chernobyl cleanup workers

Monitoring of the frequency of lymphocytes with mutations at T-cell receptor locus in Chernobyl cleanup workers

«Radiation and Risk», 2012, vol. 21, no. 1, pp.20-29

Authors

Smirnova S.G.– Senior Researcher, C. Sc., Biol.,Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: (48439) 9-71-88, e-mail:  This email address is being protected from spambots. You need JavaScript enabled to view it. .
Orlova N.V. – Senior Researcher, C. Sc., Biol.,Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Zamulaeva I.A. – Head of Lab., D. Sc., Biol., Prof.,Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Tkachenko N.P. – Head Researcher, C. Sc., Med.,Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Lozebnoy N.I. – Oncologist of Clinical Hospital N 8 FMBA of Russia, Post-graduate student of MRRC,Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Kaplan M.A. – Head of Dep., MD, Prof.,Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Tumanov K.A. – Research Assistant,Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Kashcheev V.V. – Senior Researcher, C. Sc., Biol.,Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Ivanov V.K. – Chairman of RSCRP, Deputy Director, Corresponding Member of RAMS,Medical Radiological Research Center of the Russian Ministry of Health
and Social Development, Obninsk.
Saenko A.S. – Deputy Director, D. Sc., Biol., Prof.,Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk

Abstract

Monitoring of the frequency of lymphocytes with mutations at T-cell receptor (TCR) locus in Chernobyl cleanup workers was performed 9-25 years after radiation exposure. Study group consists of 355 persons, most of them were irradiated at low doses (up to 200 mGy). Elevated frequencies of the TCR-mutant cells were found in part (12.5%) of the persons. The percentage of such persons did not significantly change within period of the examination. Individual analysis of possible changes of the mutant cell frequency was conducted in 66 persons after repeated measurements. It was found that the frequency of the TCR-mutant cells remained constant in 70% of persons and increased or decreased in 30%. It is possible to assume that these effects are caused by occurrence of radiation-induced genome instability in the part of irradiated persons. The genome instability can persist for a long time after influence (up to 25 years in our research). The effect doesn't depend on dose of the radiation exposure.

Key words
: Chernobyl cleanup workers, low doses of irradiation, somatic mutagenesis, TCR-mutations, the radiation-induced genome instability.

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