Complex treatment of tumors of the oral cavity using of photodynamic therapy

«Radiation and Risk», 2011, vol. 20, no. 1, pp.41-49

Authors

Polkin V.V. – Postgraduate Student. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: (48439) 9-32-01, fax: (48439) 9-33-58; e -mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Kaplan M.A. – Head of Dep., MD, Prof. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Medvedev V.S. – Head of Dep., MD. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Siomin D.Y. – Physician, C. Sc., Med. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Kapinus V.N. – Physician, C. Sc., Med.Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Spichenkova I.S. – Researcher, C. Sc., Med. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Isaev P.A. – Lead. Researcher, Cd. Sc., Med. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Derbugov D.N. – Physician. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.
Shubina A.M. – Senior Res., C. Sc., Med. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.

Abstract

From 2003 to 2010 51 patients with tumors of oral cavity were treated. The location of the tumor, its size, prior treatment, and the patient’s clinical status are the main indications for choosing the tactics of treatment. According to all above-mentioned all patients were divided into 4 clinical groups: only photodynamic therapy (PDT); surgery and photodynamic therapy; photodynamic therapy and gamma-ray therapy and/or simultaneous polychemotherapy; photodynamic therapy and interstitial neutron therapy by pin sources of californium-252. Complete response of tumor after PDT was independently of its localization and  extent  of  spread  in  41  patients (80.4 %), partial response – in 8 patients (15.7 %),  stabilization  –  in  2  patients (3,9 %). Thus, overall result of treatment, i.e. the complete and partial response, amounted to 96.1 %. The 2-overall survival years rate was 71.7±7.8 %. PDT was developed as the new method of organ retaining treatment of therapy of oral cavity tumors in combination with the traditional methods of treatment. PDT can be effectively used for treatment of patients with primary, recurrent or residual tumors of oral cavity.

Key words
Tumors of oral cavity, photodynamic therapy.

References

1. Davydov M.I., Axel E.M. Statistics of malignant neoplasms in Russia and CIS countries in 2007. Vestnik N.N. Blokhin ROC RAMS. 2009. Vol. 20, no. 3. Ad. 1. 158 p.

2. Daryalova S.L., Chissov V.I. Diagnosis and treatment of malignant tumors. Moscow Medicine Publ., 1993. 255 p.

3. Kaplan M.A., Sokol N.I., Spichenkova I.S. Combined radiotherapy and photodynamic therapy of the experimental tumor of M-1 sarcoma in rats. Russian biotherapeutic journal. 2003. No. 4. PP. 31-34.

4. Stranadko E.F., Markichev N.A., Ryabov M.V. Photodynamic therapy in the treatment of malignant neoplasms of various localizations: a manual for physicians. Moscow. 2002. 22 p.

5. Stranadko E.F., Titova V.A., Ryabov M.V., Petrovsky V.Yu. Photodynamic therapy as a component of combined and complex treatment of malignant neoplasms of the head and neck. Laser medicine. 2004. No. 3. PP. 150-151.

6. Paches A.I. Tumors of the head and neck. Moscow, Medicine Publ., 2000. 480 p.

7. Sanderson R.J., Ironside J.A. Squamous cell carcinomas of the head and neck. British Medical Journal. 2002. Vol. 325, no. 7368. PP. 822-827.

8. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncology. 2009. Vol. 45, no. 4-5. PP. 309-316.

Full-text article (in Russian)