The dependence of incidence rates of non-cancer thyroid diseases in the post-natal period at the Kaluga oblast children from term gestation, on which has taken place them in utero irradiation owing to technogenic iodine-131 incorporation

«Radiation and Risk», 2011, vol. 20, no. 1, pp.24-33


Gorobets V.F. – Lead. Researcher, Cand. Sc., Med. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: (48439) 9-30-11; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .


The results of investigation of non-cancer thyroid diseases incidence rates, relative risks and etiologic fractions by cohort study at 420 children from southwest region of the Kaluga oblast for the 12-year’s period after irradiation in utero on various terms of gestation at the expense of the technogenic iodine-131 incorporation are presented. Also 150 not exposed children as the control group was observed. It was established that incidence rates of thyroid diseases in the children irradiated in utero was at 2.6 times more than in the control group. The incidence of thyroid diseases among the children irradiated in utero was depended on the period of gestation at which irradiation was occurred. The most high level of the thyroid diseases incidence rate was in two subgroups of irradiated children: in the first subgroup every member was irradiated at the expense of iodine-131 from 4-th to 12-th week of gestation, in the second subgroup – from 16-th to 22-th week of gestation. It is known from radiobiological investigations that at these periods of gestation thyroid of foetus intensively accumulates radioactive iodine.

Key words
Children, incidence of non-cancer thyroid diseases, irradiation in utero, technogenic iodine-131, cohort study.


1. Album A., Norell S. Introduction to modern epidemiology. Trans. from English. Tallinn: Institute of Experiments. and clinical medicine (Estonia); The Danish Anti-Cancer Society, 1996. 122 p.

2. Biglhol R., Bonita R., Kjelstrem T. Fundamentals of Epidemiology. Trans. from English. Geneva: WHO, 1994.

259 p.

3. Drzhevetskaya I.A. Endocrine system of a growing organism. Moscow: Higher School, 1987. 207 p.

4. Ivanov V.K., Tsyb A.F. Medical radiological consequences of Chernobyl for the population of Russia: assessment of radiation risks. Moscow: Medicine, 2002. 392 p.

5. Kobozeva N.V., Gurkin Yu.A. Perinatal endocrinology: a guide for doctors. Leningrad: Medicine, 1986. 312 p.

6. Lyaginskaya A.M. Radioactive iodine and pregnancy. Healthcare of Belarus. 1987. No. 4. PP. 34-37.

7. Lyaginskaya A.M., Romanova L.K., Pokrovskaya M.S. Dangers of irradiation of the fetus. Reproductive health of women and offspring in regions with radioactive contamination. Ed. M.Ya. Fedorova et al. Moscow. Medicine Publ., 1997. PP. 246-260.

8. Morshina T.N., Bobovnikova Ts. I., Korpusova Yu.V. Study of geochemical features of a number of areas of the Kaluga region with endemic goiter. Hygiene and Sanitation. 1994. No. 3. P. 45-47.

9. Moskalev Yu.I. Actual problems of radiobiology of incorporated iodine isotopes. Kinetics of metabolism, biological effect of radioactive isotopes of iodine: coll. sci. works. Ed. Yu.I. Moskaleva, V.S. Calistratova. Moscow, 1989. PP. 7-28.

10. Moskalev Yu.I. The long-term consequences of exposure to ionizing radiation. Moscow, Medicine Publ., 1991. 464 p.

11. Orlov M.Yu., Snykov V.P., Khvalenskiy Yu.A., Volokitin A.A. Soil contamination of the European part of the territory of the USSR by iodine-131 after the Chernobyl accident. Nuclear energy. 1996. Vol. 80, Issue. 6. PP. 466-471.

12. Parshin V.S. Ultrasonic screening of the thyroid gland: dis. ... Doct. med. sciences. Obninsk, 1994. 205 pp.

13. Parshkov E.M., Sokolov V.A., Proshin A.D. Thyroid cancer in children and adults in the Bryansk region after the Chernobyl accident. Vopr. oncol. 2004. Vol. 50, no. 5. PP. 533-539.

14. Parshkov E.M., Shakhtarin V.V., Tsyb A.F., Stepanenko V.F. The problem of radiation-induced thyroid cancers in children and adolescents (Bryansk region). Medical aspects of the effect of small doses of radiation on children, adolescents and pregnant women: Sat. sci. works. Issue. 2. Obninsk, Moscow, 1994. PP. 201-207.

15. Paches A.I., Propp R.M. Cancer of the thyroid gland. 2nd ed. Moscow. Center for the Implementation of the Achievements of Science and Technology "Moscow", 1995. 372 p.

16. Average doses of thyroid gland exposure to people of different ages living in 1986 in the settlements of the Bryansk, Tula, Orel and Kaluga regions contaminated with radio nuclides as a result of the Chernobyl accident: handbook. Ed. M.I. Balonov, I.A. Zvonovoy. Ministry of Health of Russia publ., 2002. Radiation and Risk. 2002. Special Issue. PP. 3-94.

17. Ultrasonic diagnostics of thyroid gland diseases. Tsyb et al. Moscow, Meditsina Publ., 1997. 332 p.

18. Tsyb A.F. Medical consequences of the Chernobyl accident. Med. radio. and radi. security. 1998. Vol. 43, no. 1. PP. 18-23.

19. Yarmonenko S.P., Vainson A.A. Radiobiology of humans and animals. Moscow, Higher School publ. 2004. 549 p.

20. Toran-Allerand C.D. Normal development of hypothalamic-pituitary-thyroid axis: ontogeny of the neuroendocrine unit. Werner’s Thyroid. A Fundamental and Clinical Text. Eds.: S.H. Ingbar, L.E. Braverman. Philadelphia, J.B. Lippincott Co. Publ., 1986. PP. 7-23.

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