RADIATION & RISK
Bulletin of the National Radiation and Epidemiological Registry
since 1992
About the Journal : 2010 : vol. 19, No. 4 : Multimodality treatment for oropharyngeal tumors

Multimodality treatment for oropharyngeal tumors

«Radiation and Risk», 2010, vol. 19, no. 4, pp.72-79

Authors

Siomin D.Y. – Physician, Cand. Sci.; Med. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: (48439) 9-32-01, fax: (48439) 9-33-58; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Medvedev V.S. – Head of Department, MD. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia.
Mardinsky Y.S. – Head of Department, Corr. Member of RAMS, MD, Prof. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia.
Gulidov I.A. – Head of Department, MD, Prof. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia.
Isaev P.A. – Lead. Researcher, Cand. Sci., Med. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia.
Radzhapova M.U. – Lead. Researcher, Cand. Sc. Med. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia.
Derbugov D.N. – Physician. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia.
Polkin V.V. – Postgraduate Student. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia.

Abstract

The aim of this study was to analyze long-term follow-up results of a single institution's experience with a regimen of concomitant cisplatin/ftoruracil (5-FU) infusion, neutron brachytherapy (NBT) and radiation for patients with squamous cell oral and oropharygeal cancer. Two hundred thirty-seven patients were eligible for this report. After our treatment a complete tumor response was obtained in 190 (80.2%), and partial response in 44 (18.6%) patients. There was no severe long-term treatment-related toxicity. Recurrence of primary tumors was observed in 43 (18.1%) patients and recurrence of regional lymph nodes metastases in 24 (10.1%) patients. The 5-year overall survival was 64.5±3.3% (Kaplan-Meier method) irrespectively of tumor site, stage and treatment method. Our results evidence for good efficacy and safety of 252Cf NBT, radiotherapy and CCT in head and neck cancer which is not associated with functional and cosmetics defects.

Key words
Squamous cell cancer, concurrent chemoradiotherapy, radiotherapy, neutron brachytherapy.

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Full-text article (in Russian)