Effects of irradiation of germ cells of male Wistar rats on the development of posterities of two generations

«Radiation and Risk», 2010, vol. 19, no. 4, pp.58-62

Authors

Palyga G.F. – Main Researcher, MD, Prof. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: (48439) 9-70-45; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Chibisova O.F. – Research Assistant. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia.
Ivanov V.L. – Senior Researcher, C.Sc., Vet. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia.
Dergilev A.A. – Postgraduate Student. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia.
Zhavoronkov L.P. – Head of Lab., MD. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia.

Abstract

Effects of exposure germ cells of male Wistar rats to 60Co (0.5-1.0 Gy, dose rate 0.003 Gy/s be-fore copulation) on embryonic and postnatal development of posterity of two generations were studied. The more pronounced effect was observed in sibling of the first generation. Less marked radiation-induced disturbance of embryonic and postnatal development was found in the second generation. The findings indicate genome instability.

Key words
Rats Wistar, males, irradiation of spermatozoons, posterity.

References

1. Dubrova Yu.E. Instability of the genome among descendants of irradiated parents. Facts and their Interpretation. Genetics. 2006. Vol. 42, No. 10. PP. 1-10.

2. Palyga GF, Zakoschikov KF, Epatova Т.V. Influence of total gamma irradiation of females on pregnancy and postnatal development of offspring. Archive of anatomy, histology and embryology. 1984. Vol. LXXXVII, No. 12. PP. 71-76.

3. Albers-Schõnberg H.E. Űber eine bisher unbekannte Wirkung der Rǒntgenstrahlen auf den Organismus der Tiere. Mǔnchen Medicinische Wochenschrift. 1903. No.50. PP. 1859-1960.

4. Clermont Y., Leblond C., Messier B. Dures du cycle de l'epithehelium seminaliandu Raat. Archiv Anat., Microsc., Morphol. Exp. 1959. B. 48. PP. 37-56.

Full-text article (in Russian)