Estimation of absorbed internal doses in laboratory animals after injection radiopharmaceuticals labeled by Tc-99m and Re-188

«Radiation and Risk», 2010, vol. 19, no. 4, pp.50-57

Authors

Yaskova E.K. – Lead. Researcher, C.Sc., Biol. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: (495) 956-14-40, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. ; This email address is being protected from spambots. You need JavaScript enabled to view it. .
Stepanenko V.F. – Head of Lab., Dr.Sc., Biol. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia.
Petriev V.M. – Lead. Researcher, C.Sc., Biol. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia.
Skvortsov V.G. – Head of Lab., C.Sc., Biol. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia.
Sokolov V.A. – Lead. Researcher, C.Sc., Biol. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia.
Kryukova I.G. – SeniorResearcher, Cand. Sci., Biol. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia.
Shiryaeva V.K. – Researcher. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia.
Belorukova N.V. – Research Assistant; Dubov D.V. – Postgraduate Student. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia.
Kalashnikova E.E. – Research Assistant. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia.
Tsyb A.F. – Director, Academician of RAMS. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk, Russia.

Abstract

The high level of selective accumulation of two radiopharmaceuticals (POEDP, labeled by 99mTc and 188Re) in bone tissue was shown. It means that these radiopharmaceuticals are suitable for diagnostic and/or therapeutic purposes in case of bone metastases. The absorbed doses in critical organs (kidneys, liver, small intestine, lungs) are much less than absorbed dose in bone tissue.

Key words
Internal irradiation, absorbed doses, Tc-99m, Re-188, radiopharmaceuticals.

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Full-text article (in Russian)