RADIATION & RISK
Bulletin of the National Radiation and Epidemiological Registry
since 1992
About the Journal : 2010 : vol. 19, No. 3 : Attractive and immunosuppressive properties of volatile secretions induced in mice separately and combine the influence of ionizing radiation and chemicals

Attractive and immunosuppressive properties of volatile secretions induced in mice separately and combine the influence of ionizing radiation and chemicals

«Radiation and Risk», 2010, vol. 19, no. 3, pp.94-103

Authors

Abramova M.R. – Research Assistant. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel. (48439) 9-71-61; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Surinov B.P. – Head of Lab., Dr Sc., Biol. Medical Radiological Research Center of the Russian Ministry of Health and Social Development, Obninsk.

Abstract

Abstract

We have studied the properties of volatile secretions induced in laboratory mice, separate or combined influence of ionizing radiation and chemical compounds (ChC), such as benzene (BZ), as well as one of the products of its metabolism – hydroquinone (GC). The reaction of preference-avoidance response in the T-maze revealed that in urine samples of mice early after exposure to ionizing radiation at doses of 2 and 4 Gy contain attractive for intact animals volatile components (VC). The introduction of BZ in a dose of 2.8 g/kg, as well as the GC in a dose of 100 mg/kg provokes the secretion of VC of aversive, repealing properties towards of intact individuals. Combined exposure to these factors leads to a reciprocal compensation of the impact of volatile secretions in the preference-avoidance response of intact mice. The examined effects depend to some extent on the dose of radiation and CC. Induced both by separate and associated exposure to radiation and CC volatile components have depressing effect of the humoral immune response, regardless of whether they are attractive or aversive properties. Induced both by separate and associated exposure to radiation and CC volatile allocation have a depressing effect of the humoral immune response, regardless of whether they are attractive or aversion properties. We are discussing the role mechanisms of chemosignaling in the development of post-radiation reactions in groups of animals.

Key words
Ionizing radiation, chemicals, combined influence, mice volatile secretions, behaviors and immune reactions.

References

1. Kuzin A.M. Structural-metabolic hypothesis in radiobiology. Moscow, Nauka Publ., 1970. 221 p.

2. Moshkin M.P., Gerlinskaya LA, Evsikov V.I. The immune system and the realization of behavioral strategies of reproduction in parasitic presses. Zhurn. general biology. 2003. Vol. 64, no. 1. PP. 23-44.

3. Novikov S.N. Pheromones and reproduction of mammals. Science Publ., 1988. 196 pp.

4. Novikov V.S., Smirnov V.S. Immunophysiology of extreme conditions. SPb. Science Publ., 1995. 172 p.

5. Rumyantseva G.M., Chinkina O.V., Bezhina L.N. Radiation incidents and psychological health. Moscow. FGULGNTSSSP Publ., 2009. 288 p.

6. Sokolov V.E. Chemical communication of mammals. Successes of modern theriology. Moscow. Nauka Publ., 1977. pp. 229-254.

7. Surinov B.P. Aversive, repulsive intact individuals, chemosignals of mice with radiation, toxic lesions and malignant growth. DAN. 2007. Vol. 414, No. 4. PP. 554-556.

8. Surinov BP, Isaeva V.G. Immunomodulating effects of volatile discharges of animals with postradiation immunodeficiency states. Radiats. Biol. Radioecol. 2008. Vol. 48, no. 6. PP. 665-670.

9. Surinov B.P., Isaeva V.G., Dukhova N.N. Communicative Multiplication of Secondary Disorders of Blood Indicators and Immunity in Groups of Intact Mice Mediated by Volatile Isolation of Irradiated Species. Radiats. Biol. Radioecol. 2004. Vol. 44, no. 4. PP. 387-391.

10. Surinov B.P., Isaeva V.G., Dukhova N.N. Postradiation immunosuppressive and attractive volatile discharges: "neighbor effect (baystander effect)" or allelopathy in animal groups, "Dokl. RAS. 2005. Vol. 400, no. 5. PP. 711-713.

11. Surinov B.P., Isaeva V.G., Karpova N.A., Kulish Yu.S. Immunosuppressive activity of volatile discharges of stressed and irradiated animals. Immunology. 2001. No. 5. PP. 39-42.

12. Surinov B.P., Shpagin D.V. Influence of irradiation on the olfactory ability of male mice to distinguish chemosignals of intact individuals. Radiats. Biol. Radioecol. 2007. Vol. 47, no. 1. PP. 17-21.

13. Sharetsky A.N., Surinov B.P., Abramova M.R. Immunosuppressive activity of volatile urine components of mice exposed to immunosuppressants. Immunology. 2003. Vol. 24, no. 5. PP. 269-272.

14. Sharetsky A.N., Surinov B.P., Abramova M.R. Immunosuppressive effect of volatile discharges of mice exposed to cadmium, lead and aluminum salts. Chemical and Biological Safety. 2008. Vol. 37-38, No. 1-2. PP. 7-11.

15. Beauchamp G.K., Yamazaki K. Chemical signallig in mice. Biochem. Soc. Trans. 2003. Vol. 31. PP. 147-151.

16. Hurst J.L., Beynon R.J. Scent wars: the chemobiology of competitive signaling in mice. Bioessays. 2004. Vol. 26. PP. 1288-1289.

17. Kavaliers M., Colwell D.D. Odours of parasitised males induce aversive response in female mice. Animal Behaviour. 1995. Vol. 50. PP. 1161-1169.

18. Novotny M., Soini H.A., Koyama S. et al. Chemical identification of MHC – influenced volatile compounds in mouse urine. J. Chem. Ecol. 2007. V. 33. P. 417-434.

19. Penn D.J., Potts W.K. Chemical signals and parasite-mediated sexual selection. Trens Ecol. Evol. 1998. V. 13. C. 391-396.

20. Schwende F.J., Gorgenson G.W., Novotny M. Possible chemical basis for histocompatibility-related mat-ing preference in mice. J. Chem. Ecol. 1984. Vol. 10. PP. 1603-1615.

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