Age-gender dependencies of cancer pathology development among population living in the contaminated territories after the Chernobyl accident

«Radiation and Risk», 2009, vol. 18, no. 3, pp.62-76

Authors

Parshkov E.M.1 – Head of Department, MRRC RAMS, Professor, MD. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: (48439) 9-32-86; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .
Sokolov V.A.1 – Leading Researcher, Cand. Sc., Biol.
Golivets T.P.2 – Assistant Professor, Cand. Sc., Med. Belgorod State University.
Kovalenko B.S.1 – Head of Department, Cand. Sci., Med., Belgorod State University.
Artamonova Y.Z.2 – Leading Engineer, MRRC RAMS.

Abstract

Descriptive epidemiological analysis of more than 200 thousands of new cancer cases over 25-year period (1981-2005) among population of the Belgorod and Bryansk Regions affected as a result of the Chernobyl accident was carried out. Age-gender dependencies of population oncopathology development during this period as well as the dynamics the incidence changes in separate nosological units were determined. It was shown that exposure in low dose after the Chernobyl accident led to wavy change of the incidence with the period 5-7 years and that radiation-induced incidence developed in the format of spontaneous one. The role of physiological factors of organism and processes of cell proliferation and differentiation in cancer development are discussed.

Key words
Chernobyl accident, oncology, population incidence, descriptive epidemiological analysis, mechanisms of carcinogenesis, Belgorod and Bryansk Regions.

References

. Atlas of radioactive contamination in the European part of Russia, Belarus and Ukraine after the accident at the Chernobyl Nuclear Power Plant. Yu.A. Israel. Moscow, IGKE Roshydromet, Roskartografiya Publ., 1998.

2. Golivets T.P. Thyroid cancer in children and adults in the Belgorod region in the post-Chernobyl period (15-year experience of observation). Sovrem. oncology. 2002. No. 5. PP. 193-196.

3. Golivets T.P., Parshkov E.M., Kovalenko B.S. The dynamics of the incidence of breast cancer in women in the Belgorod region for the period from 1981 to 2005. Palliative medicine and rehabilitation. 2009. No. 3, PP. 16-19.

4. Ivanov V.K., Tsyb A.F. Medical radiological consequences of Chernobyl for the population of Russia: assessment of radiation risks. Moscow, Medicine, 2002. 392 p.

5. Il'in L.A., Balonov M.I., Buldakov L.A. et al. Ecological features and medical and biological consequences of the Chernobyl accident. Medical radiology. 1989. No.11. PP. 58-81.

6. Zaitsev V.M., Liflyandsky V.G., Marinkin V.I. Applied medical statistics. St. Petersburg, Folio Publ, 2003. 429 p.

7. Malignant neoplasms in Russia in 1980-1995. Ed. Chisov V.I., Starinskiy V.V., Remennik L.V. Moscow, MNIOI Publ., 1998. P. 167.

8. Carcinogenesis. Ed. Zaridze D.G. Moscow, Medicine Publ., 2004. 576 p.

9. Lushnikov E.F., Tsyb A.F., Yamashita S. Cancer of the thyroid gland in Russia after Chernobyl. Мoscow, Public Corporation "Medicine" Publ., 2006. 128 p.

10. Okeanov A.E., Yakimovich A.V. Incidence of malignant neoplasms among the population of the Gomel Region after the Chernobyl disaster. Intern. Journal of Radiation Medicine. 1999. Vol. 1, No. 1. PP. 49-54.

11. Parshkov E.M., Sokolov V.A., Proshin A.D. Thyroid cancer in children and adults in the Bryansk region after the Chernobyl accident. Vopr. oncol. 2004. Vol. 50, no. 5. PP. 533-539.

12. Parshkov E.M., Sokolov V.A., Golivets T.P. Some regularities of population carcinogenesis. Proc. V Congress of Oncologists and Radiologists CIS, Tashkent May 14-16, 2008 Tashkent, 2008. P. 49.

13. Parshkov E.M., Sokolov V.A., Golivets T.P. Population morbidity in the territories affected by the Chernobyl accident. Biological effects of small doses of ionizing radiation and radioactive contamination of the environment (BIORAD-2009). Proc. Intern. Conf., Syktyvkar, September 28-October 1, 2009 Syktyvkar, 2009. PP. 258-260.

14. Prisyazhnyuk A.E., Grishchenko V.G., Fedorenko Z.P. and others. Epidemiological study of malignant neoplasms in the victims of the Chernobyl accident. Results, problems and prospects. Intern. Journal of Radiation Medicine. 1999. Vol. 2, no. 2. PP. 42-50.

15. Collections "Malignant neoplasms in Russia", published by the Institute in 1996-2006.

16. Cherezov A.E. The general theory of cancer is the tissue approach. Moscow, Moscow State University Publ., 1997. 251 p.

17. Burlakova E.B., Antova Yu.S., Goloshchapov A.N. et al. Mechanisms of biological action of low-dose irradiation. In: Consequences of the Chernobyl Catastrophe on Human Health (Editor E.B.Burlakova). Nova Science Publishers Inc. Commack, New York, 2002. PP. 11-38.

18. Cardis E., Amoros E., Kesminiene A. et al. Observed and predicted thyroid cancer incidence following the Chernobyl accident evidence for factors influencing susceptibility to radiation induced thyroid cancer. Radiation and Thyroid Cancer. Editors: G.Thomas, A.Karaoglou, E.D.Williams. World Scientific Publishing Co. Pte. Ltd., 1999. PP. 395-405.

19. Cardis E., Kesminie A., Ivanov V. et al. Risk of thyroid cancer after exposure to iodine-131 in childhood. J. Natl. Cancer Inst. 2005. Vol. 97, no. 10. PP. 724-732.

20. Parshkov E., Sokolov V., Tsyb A. et al. Radiation-induced thyroid cancer: what we know and what we really understand. Int. J. Low Radiation. 2004. Vol. 1, no. 3. PP. 267-278.

21. Parshkov E.M. Pathogenesis of radiation-induced thyroid cancer in children affected as a result of the Chernobyl accident. Int. J. of Radiation Medicine. 1999. Vol. 3-4. РP. 67-75.

22. Parshkov E., Sokolov V., Tsyb A. et al. Physiological factors in the analysis of radiation-induced thyroid cancer. The Effects of Low and Very Low Doses of Ionizing Radiation on Human Health. Amsterdam: Elsevier Science B.V., 2000. PP. 393-399.

23. Polyakov S.M., Piliptsevich N.N., Malakhova I.V. et al. Cancer incidence in Belarus after the Chernobyl accident. Chernobyl: Message for the 21st Century (Proc. of the Sixth Chernobyl Sasakawa Symposium). Moscow, 30-31 May 2001. Elsevier, 2002. PP. 253-266.

24. Ron E., Lubin J., Schore R. et al. Thyroid cancer after exposure to external radiation: A pooled analysis of seven studies. Radiat. Res. 1995. Vol. 141, no 3. PP. 259-277.

25. UNSCEAR 2000. Report to the General Assembly. Annex J. Exposures and Effects of the Chernobyl Accident. New York: U.N., 2001. 106 p.

26. Von Wangenheim K.H., Peterson H.P. The role of cell differentiation in controlling cell multiplication and cancer. J. Cancer Res. Clin. Oncol. 2008. Vol. 134, no. 7. PP. 725-741.

27. Weinberg R.A. The Biology of Cancer. Garland Science, 2006. 864 p.

28. Wright E.G., Coates P.J. Untargeted effects of ionizing radiation: Implication for radiation pathology. Mutat. Res. 2006. Vol. 597. PP. 119-132.

Full-text article (in Russian)