Prediction of synergistic effects of sequentional thermoradiation action

«Radiation and Risk», 2008, vol. 17, no. 4, pp.55-66

Authors

Kritsky R.O. - Graduate Student. Medical Radiological Research Center of RAMS, Obninsk.
Belkina S.V. - Researcher. Medical Radiological Research Center of RAMS, Obninsk.
Zhurakovskaya G.P. - Leading Researcher. Medical Radiological Research Center of RAMS, Obninsk.
Petin V.G. - Laboratory Head. Medical Radiological Research Center of RAMS, Obninsk. Contacts: 249036, Kaluga Region, Obninsk, ul. Koroleva, 4. Tel .: (48439) 7-47-70; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it. .

Abstract

The dependence of synergy enhancement ratio after the consecutive thermoradiation actions on dose rate and dose of ionizing radiation as well as on temperature and duration of its applicat

Kritsky R.O., Belkina S.V., Zhurakovskaya G.P., Petin V.G.
«Radiation and Risk», 2008, vol. 17, no. 4, pp.55-66

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«Radiation and Risk», 2008, vol. 17, no. 4, pp.55-66

Authors

Kritsky R.O., Belkina S.V., Zhurakovskaya G.P., Petin V.G.

Abstract

The dependence of synergy enhancement ratio after the consecutive thermoradiation actions on dose rate and dose of ionizing radiation as well as on temperature and duration of its application was studied for yeast cells. The results published before were described and interpreted by means of the mathematical model of synergism in accordance with which the synergism is expected to result from the additional lethal damage arising from the interaction of sublesions induced by both agents.

Key words
Synergism, combined impact, mathematical model, ionizing radiation, hyperthermia.

References

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