Prediction of synergistic effects of ionizing radiation and different harmful agents on mammalian cells and plants

«Radiation and Risk», 2006, vol. 15, no. 3-4, pp.120-132


Belkina S.V., Komarova L.N., Kritzkiy R.O.
Medical Radiological Research Centre, Obninsk.


The possibility of prediction of synergistic effects of ionizing radiation and different damaged factors on mammalian cells and plants has been performed. The model describes the data on combined action of these agents on the survival, cell transformation and the yield of mutation. It was shown that experimental results agreed with the predicted synergistic effectiveness. The model predicts the values of the synergistic enhancement ratio at any ratio of damages induced by the acting agents as well as the highest synergistic effect and the condition under which it is achieved.

Key words
Prediction, synergistic effects, combined action, ionizing radiation, model, survival, cell transformation, yield of mutations.


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