Certain regularities of adaptive response of dividing populations of Saccharomyces cerevisiae to ionizing radiationyroid abnormalities among children of the south-west area of the Kaluga oblast exposed to radiation in utero during different periods of gestation

«Radiation and Risk», 2006, vol. 15, no. 1-2, pp.59-67

Authors

Gorshkova T.A.
Medical Radiological Research Center of RAMS, Obninsk.

Abstract

The results of adaptive response investigation for dividing cell populations of diploid yeast Saccharomyces cerevisiae are presented. The existence of both the smallest dose rate producing the adaptive response and the range of doses and dose rates of γ-radiation within which the adaptive response to the following irradiation was the highest. The adaptive response of dividing yeast cells was registered by pretreatment not only by low but also high damaging doses. Adaptive response was expressed in increase of survival and in acceleration of colony appearance produced by irradiated cells.

Key words
Adaptive response, population of diploid yeast cells, Saccharomyces cerevisiae, threshold dose rate, γ-radiation, dose interval, dose-damaging, survival.

References

1. Bodnarchuk I.A. Hypothesis on the mechanism of induction of the adaptive response in the irradiation of mammalian cells in small doses. Radiation Biology. Radioecology. 2002. Vol. 42, No. 1. PP. 36-42.

2. Zyuzikov N.A., Korogodin V.I., Korogodina V.L. Features of the action of small doses of γ-radiation on yeast cells. Radiation Biology. Radioecology. 1999. Vol. 39, No. 6. PP. 619-622.

3. Semenets T.N., Semina O.V., Sayenko A.S. Phenomenon of adaptive resistance to γ-irradiation of colony-forming units (CFU-C): conditions of manifestation in exotest. Radiation Biology. Radioecology. 1993. Vol. 33, Issue. 4. PP. 525-528.

4. Serebryany A.M., Morozova I.S., Zoz N.N. To the nature of the adaptive response in plants. Radiation Biology. Radioecology. 1994. Vol. 34, Issue. 6. PP. 818-826.

5. Spitkovsky D.М. Biological effect of small doses of ionizing radiation. Radiobiology. 1992. Vol. 32, No. 3. PP. 382-400.

6. Filippovich I.V. Phenomenon of the adaptive response of cells in radiobiology. Radiobiology. 1991. T. 31, No. 3. P. 803-814.

7. Eydus L.H. About a single mechanism of initiation of various effects of small doses of ionizing radiation. Radiation Biology. Radioecology. 1996. T. 36, Issue. 6. P. 874-882.

8. Durand J.L., Van Broock M., Frati D.L. et al. Adaptive response to ionizing radiation on Saccharomyces cerevisiae. Radiobiologia. 2002. Vol. 2, no. 1. PP. 18-22.

9. Dutta K. Exposure to low dose of gamma radiation enchances the excision repair in Saccaromyces cerevisiae. J. Gen. Appl. Microbiol. 1998. Vol. 44, no. 4. PP. 243-249.

10. Ryabchenco N. I., Antochina M.M., Fesenco E.V. et al. Cytogenetic adaptive response in cultured human lymphocytes: dependence on the time of exposure to adapting and challenging doses of γ rays. Mutat. Res. 1998. Vol. 418, no. 1. PP. 7-19.

Full-text article (in Russian)