Study of antithyroid autoimmunity status in children residing in ecologically unfavorable south-west area of the Kaluga oblast

«Radiation and Risk», 2006, vol. 15, No. 1-2, pp.38-48

Authors

Gorobets V.F.
Medical Radiological Research Center of RAMS, Obninsk.

Abstract

Time changes of prevalence of raised concentration of antibodies to microsomal antigen of thyrocytes and to thyroglobulin was studied in 6 450 samples of blood sera taken from patients (3 148 men and 3 302 women) born from 1968 to 1986 who resided in Zhizdrinsky, Ulianovsky and Khvastovichsky raions of the Kaluga oblast in 1986. The thyroid of the subjects was exposed to incorporated iodine-131 in May-July 1986 as a result of the Chernobyl accident. The follow-up covers the period from 1987 over 1998. The results of the assay were compared with those of blood sera taken from 1 190 children (604 boys and 586 girls) born in 1987-1997, their thyroid was not exposed to iodine-131. In people with exposed thyroid the frequency of raised concentration of antithyroid antibodies was found to depend on the age at exposure. The older people were at the time of exposure the frequency of raised titer of antibodies to microsomal antigen decreased. The prevalence of the raised level of antithyroid antibodies depended on sex, it was higher in women than in men. In children with unexposed thyroid no dependence of the raised concentration of antithyroid sntibodies on sex was detected. This fact says that the thyroid in women is more sensitive to radiation than that in men. In both groups the frequency of raised level of antithyroid antibodies was higher in patients with thyroid abnormalities. In exposed patients with autoimmune thyroiditis high titers of antibodies to microsomal antigen were found in 96.08% of persons, high titers of antibodies to thyroglobulin were found in 43.14% only. In this group high titers of antibodies to thyroglobulin were detected more frequently (7.65% against 2.96%) and high titers of antibodies to microsomal antigen were detected more seldom (3.83% against 7.25%) if the level of thyrotropin content in blood was high. In the same group there was a trend of relationship between titer of antibodies to microsomal antigen and individual absorbed thyroid dose from iodine-131 and such tendency was not found for antibodies to thyroiglobulin.

Key words
Detection frequency, elevated levels, blood serum, autoantibodies, microsomal antigen of thyroid cells, At-MA, thyroglobulin, At-TG, children, iodine-131.

References

1. Avramenko N.L. Function of thyroid gland and specific autoimmune reactions in children of Narodichsky district of Zhytomyr region 2.5 years after the accident at Chernobyl NPP: Author's abstract. dis. ... cand. med. sciences. Obninsk, 1992. 18 p.

2. Epstein E.V., Oleinik V.A., Tronko N.D. Possible lesions of the thyroid gland in children exposed to iodine radionuclides as a result of the Chernobyl accident. Probl. endocrinol. 1992. Vol. 38, No. 4. P. 21.

3. Mishagin V.A. Radiation damage to the thyroid gland in people living under conditions of goitre endemia. Methods of diagnosis and therapy: Author's abstract. dis. ... Doct. med. sciences. Moscow, 1994. 32 p.

4. Demidchik E.P., Tsyb A.F., Lushnikov E.F. Thyroid cancer in children (consequences of the Chernobyl accident, Moscow: Medicine, 1996. 208 p.

5. Tsyb A.F. Medical consequences of the Chernobyl disaster. Med. radiology and radiation security. 1998. Vol. 43, no. 1. PP. 18-23.

6. Volpe R., ed. Autoimmune Diseases of the Endocrine System. Boca Raton: CRC, 1990. PP. 1-364.

7. Weetman A.P., McGregor A.M. Autoimmune thyroid disease: further developments in our understanding. Endocr. Rev. 1994. Vol. 15. P. 788-830.

8. Volpe R. Autoimmune diseases of the thyroid gland. Diseases of the thyroid gland. Ed. L.I. Braverman; Trans. from English. Moscow, Medicine Publ., 2000. PP. 140-172.

9. Roit A. Fundamentals of Immunology. Trans. with English. Moscow, Mir Publ., 1991. 328 p.

10. Levit I.D. Autoimmune thyroiditis (etiology, pathogenesis, clinic, diagnosis, treatment). Chelyabinsk,South-Ural Publ., 1991. 256 p.

11. Rafibekov D.S., Kalinin A.P. Autoimmune thyroiditis. Bishkek: Kyrgyz Publ. Med. Academy, 1996. 158 p.

12. Maxon H.P., Saengler E.L. Clinically important radiation associated thyroid disease. Rev. Med. Int. 1993. Vol. 14, no. 10. PP. 997-1006.

13. Braverman L.E. Iodine induced thyroid disease. Acta Med. Australia. 1990. V. 17, Suppl. 1. P. 20-38.

14. Lyubushkina S.G. Landscape characteristics of the Bryansk-Zhizdrinsky woodland and the experience of its evaluation for agriculture: Diss. ... Dr. Biol. sciences. Moscow, 1967. 238 p.

15. Orlov M.Yu., Snykov V.P., Khvalenskiy Yu.A. et al. I-131 soil contamination of the European part of USSR territory after the accident at the Chernobyl nuclear power plant. Atomic Energy. 1996. Vol. 80, no. 6. PP. 466-471.

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