Mortality in Chernobyl clean-up workers: analysis of dose-effect relationship

Issues

Authors

Ivanov V.K., Tumanov K.A., Kashcheev V.V., Tsyb A.F., Marchenko T.A.¹, Chekin S.Yu., Maksioutov M.A., Petrov A.V., Biryukov A.P.
Medical Radiological Research Center of RAMS, Obninsk.
¹Department for Infrastructure Development, EMERCOM of Russia, Moscow.

Abstract

In the article dynamics of mortality rates and radiation mortality risks in Chernobyl clean-up workers (liquidators) for the period from 1992 over 2002 is analyzed. Total cohort size is 61 017 persons. Statistically significant (p=0.03) radiation risk (ERR) from external radiation for dying from all cancers except for neoplasms of lymphoid and hematopoietic tissues was found in liquidators of the first year following the Chernobyl accident. The risk magnitude is 1.52/Gy (95% CI: 0.20-2.85). 125 cases (95% CI: 20-200) or 19% (95% CI: 3-31%) of 651 registered deaths from cancer were related to external radiation dose. Positive dose-related trend from exposure to external radiation in mortality from bronchuses and lung cancers (ERR=1.89; 95% CI: -1.34-5.12), and non-cancer diseases, such as cardiac deficiency (ERR=0.71; 95% CI: -0.06-2.04) and cerebrovascular diseases (ERR=1.79; 95% CI: -0.12-3.72) was found.

Key words
Dynamics of mortality rates, radiation risks, mortality, Chernobyl clean-up workers, liquidators, Chernobyl accident, malignant neoplasms, external radiation dose, cerebrovascular diseases, lung cancer, non-cancer diseases.

References

1. Ivanov V.K., Gorski A.I., Maksioutov M.A. et al. Mortality among the Chernobyl emergency workers: estimation of radiation risks (preliminary analysis). Health Physics. 2001. Vol. 81, No. 5. PP. 514-521.

2. Ivanov V.K., Maksioutov M.A., Chekin S.Yu. et al. Radiation-epidemiological analysis of incidence of non-cancer diseases among the Chernobyl liquidators. Health Physics. 2000. Vol. 78, No. 5. PP. 495-501.

3. Ivanov V.K., Maksioutov M.A., Chekin S.Yu. et al. The risk of radiation-induced cerebrovascular disease in Chernobyl emergency workers. Health Physics. 2006. Vol. 90, No. 3. PP. 199-207.

4. Howe G.R., Zablotska L.B., Fix J.J. et al. Analysis of the mortality experience amongst U.S. nuclear power industry workers after chronic low-dose exposure to ionizing radiation. Radiation Research. 2004. Vol. 162. PP. 517-526.

5. Cardis E., Vrijheid M., Blettner M. et al. Risk of cancer after low doses of ionising radiation-retrospective cohort study in 15 countries. BMJ. 2005. Vol. 89. PP. 1-7.

6. Ivanov V., Ilyin L., Gorski A. et al. Radiation and epidemiological analysis for solid cancer incidence among nuclear workers who participated in recovery operations following the accident at the Chernobyl NPP. J. Radial. Res. 2004. Vol. 45, No. 1. PP. 41-44.

7. Ivanov V.K., Tsyb A.F., Rastopchin E.M. et al. Cancer incidence among nuclear workers in Russia based on data from the Institute of Physics and Power Engineering: a preliminary analysis. Radiation Research. 2001. Vol. 155. PP. 801-808.

8. Preston D.L., Lubin J.H., Pierce D.A. et al. EPICURE. Seattle, USA: Hirosoft International Corporation, 1993.

9. Pierce D.A., Shimizu Y., Preston D.L. et al. Studies of the mortality of atomic bomb survivors. Report 12, Part I. Cancer: 1950-1990. Radiation Research. 1996. Vol. 146. PP. 1-27.

10. Pierce D.A., Mendelsohn M.L. A model for radiation-related cancer suggested by atomic bomb survivor data. Radiation Research. 1999. Vol. 52, No. 6. PP. 642-654.

11. Shimizu Y., Pierce D.A., Preston D.L. et al. Studies of the mortality of atomic bomb survivors. Report 12, Part II. Noncancer mortality: 1950-1990. Radiation Research. 1999. Vol. 152, No. 4. PP. 374-389.

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