The main results of the radiation-epidemiological analysis of RGMDR data (on the 20th anniversary of Chernobyl)

"Radiation and Risk", 2003, Special Issue, pp.6-11


Ivanov V.K., Tsyb A.F., Maksyutov M.A., Gorsky A.I., Marchenko T.A. 1, Kaidalov O.V., Korelo A.M., Chekin S.Y., Petrov A.V., Biryukov A.P., Kochergina E.V., Kruglova Z.G., Zelenskaya N.S., Vlasov O.K., Shchukina N.V., Kashcheeva P.V., Tumanov K.A., Mikhalsky A.I.2
Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk.
1 Infrastructure Development Department, EMERCOM of Russia, Moscow.
2 Institute for Management Problems, Russian Academy of Sciences, Moscow.


The paper presents the main results of the radiation-epidemiological analysis of RGMDR data (on the 20th anniversary of Chernobyl). The analysis of the dynamics of thyroid cancer incidence rates in the areas contaminated with radionuclides, the assessment of current risks and prognosis were carried out. The incidence of thyroid cancer among children and adolescents, residents of the Bryansk region after the Chernobyl accident, radiation risks of leukemia, non-oncological diseases among the liquidators and the population of radioactively contaminated areas, and solid cancers among the liquidators were evaluated. Considered quality control of medical information during radiation epidemiological analysis. The article analyzes the dose dependence of the death rate of the liquidators. consequences of the accident at the Chernobyl NPP, the radiation risks of cancer incidence were assessed taking into account the heterogeneity of background age indicators.

Dynamics of morbidity indicators, thyroid cancer, areas contaminated with radionuclides, the Chernobyl NPP accident, liquidators, solid cancers, non-oncological diseases, dose dependence of mortality, radiation risks, cancer.


1. Likhtarev I.A., Sobolev B.G., Kairo I.A., Tronko N.D., Bogdanova T.I., Oleinic V.A., Epshtein E.V., Beral V. Thyroid cancer in the Ukraine. Nature.1995.V. 375.P. 365.

2. Jacob P., Goulko G., Heidenreich W.F., Likhtarev I.A., Kairo I.A., Tronko N.D., Bogdanova T.I., Kenigsberg J., Buglova E., Drozdovitch V., Beral V. Thyroid cancer risk to children calculated. Nature. 1998. V. 392. PP. 31-32.

3. Radiation and Thyroid Cancer. Proceedings of an International Seminar on Radiation and Thyroid Cancer /Eds. Thomas G., Karaoglou A., Willliams E.D.Brussels-Luxembourg: World Scientific Publishing, 1999.

4. Ivanov V.K., Gorsky A.I., Tsyb A.F., Maksyoutov M.A., Rastopchin E.M. Dynamics of thyroid cancer in-cidence in Russia following the Chernobyl accident. J. Radiol. Prot. 1999. V. 19, No. 4. PP. 305-318.

5. Ivanov V.K., Gorski A.I., Pitkevitch V.A., Tsyb A.F., Cardis E., Storm H. Risk of radiogenic thyroid cancer in Russia following the Chernobyl accident /Eds. Thomas G., Karaoglou A., Willliams E.D. Proceedings of an International Seminar on Radiation and Thyroid Cancer.Brussels-Luxembourg: World Scientific Publishing, 1999. PP. 89-96.

6. Heidenreich W.F., Kenigsberg Y., Jacob P., Buglova E., Gulko G., Paretzke H.G., Demidchik E.P., Golovneva A. Time trends of thyroid cancer incidence in Belarus after Chernobyl accident. Radiation Res. 1999. V. 151. PP. 617-625.

7. Jacob P., Kenigsberg Y., Zvonova I., Gulko G., Buglova E., Heidenreich W.F., Golovneva A., Bratilova A.A., Drozdovitch V., Kruk J., Pochtennaja G.T., Balonov M., Demidchik E.P., Paretzke H.G. Childhood exposure due to the Chernobyl accident and thyroid cancer risk in contaminated areas of Belarus and Russia. British J. of Cancer. 1999.V. 80, No. 9. PP. 1461-1469.

8. Likhtarev I.A., Kairo I.A., Shpak V.M. et al. Radiation-induced and background thyroid cancer of Ukranichildren (dosimetric approach). Int. J. Radiat. Med. 1999. V. 3-4. PP. 51-66.

9. Ivanov V.K., Gorski A.I., Tsyb A.F., Maksioutov M.A., Vlasov O.K., Godko A.M. Risk of radiogenic thyroid cancer in the population of the Bryansk and Oryol regions of Russia after the Chernobyl accident (1991-1998).Chernobyl: Message for the 21st Century: Proceedings of the Sixth Chernobyl Sasakawa Medical Cooperation Symposium, Moscow, Russia, 30-31 May 2001 (International Congress Series No. 1234) /Editors Shunichi Yamashita, Yoshisada Shibata, Masaharu Hoshi, Kingo Fujimura.Amsterdam-London-New York-Oxford-Paris-Shannon-Singapore-Tokyo: ELSEVIER, 2002. PP. 85-93.

10. Ivanov V.K., Gorski A.I., Maksioutov M.A., Vlasov O.K., Godko A.M., Tsyb A.F., Tirmarche M., Valenty M., Verger P. Thyroid cancer incidence among adolescents and adults in the Bryansk region of Russia following the Chernobyl accident. Health Phys. 2003. V. 84, No. 1. PP. 46-60.

11. Winkelmann R.A., Okeanov A., Gulak L., Remennik L., Rahu M., Storm H.H. Cancer registration tech-niques in the New Independent States of the former Soviet Union. IARC Technical Report N. 35.Lyon: IARC, 1998. PP. 22-43.

12. Reference book of mean thyroid doses in persons of different age resident in the population points of the Bryansk, Tula, Oryol and Kaluga oblasts contaminated after the Chernobyl accident in 1986. Edited by M.I.Balonov and I.A. Zvonova. Bulletin of the National Radiation Epidemiology Registry, special issue, 2002 (in Russian).

13. Methodology for reconstruction of thyroid doses from iodine radioisotopes in residents of the Russian Federation exposed to radioactive contamination as a result of the Chernobyl accident in 1986. Guide-lines MU-2.6.1-00b, 2000 (in Russian).

14. Preston D.L., Lubin J.H., Pierce D.A. and McConney M.E. EPICURE.Seatle, USA: Hirosoft International Corporation, 1993.

15. Thompson D.E., Mabuchi K., Ron E., Soda M., Tokunaga M., Oshikubo S., Sugomoto S., Ikeda T., Terasaki M., Izumi S., Preston D.L. Cancer incidence in atomic bomb survivors. Part II: Solid tumors, 1958-1987. Radiation Res. 1994. V. 137. PP. S17-S67.

16. Shore R.E. Issues and epidemiological evidence regarding radiation-induced thyroid cancer. Radiation Res.1992.V. 131.P. 98-117.

17. Ron E., Lubin J.Y., Shore R.E., Mabuchi K., Modan B., Pottern L.M., Shneider A., Tucker M., Boice J.D. Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies. Radiation Res. 1995. V. 141. PP. 259-277.

18. Preston D., Kusumi S., Tomonaga M., Izumi S., Ron E., Kuramato A., Kamada N., Dohy H., Matsui T., Nonaka H., Thompson D., Soda M., Mabuchi K. Cancer Incidence in Atomic Bomb Survivors. Part III: Leukemia and Multiple Myeloma, 1950-1987. Radiation Research. 1994. V. 137. P. S94.

19. Ivanov V.K., Tsyb A.F., Gorsky A.I., Maksyutov M.A., Rastopchin E.M., Konogorov A.P., Korelo A.M., Biryukov A.P., Matiash V.A. Leukaemia and thyroid cancer in emergency workers of the Chernobyl acci-dent: estimation of radiation risks (1986-1995). Radiat. Environ. Biophys. 1997. V. 36. PP. 9-16.

20. Cardis E., Gilbert E.S., Carpenter L. et al. Effects of low doses and low dose rates of external ionizing radiation: cancer mortality among nuclear workers in three countries. Radiation Research. 1995. 143. PP. 117-132.

21. Preston D.L., Lubin J.H., Pierce D.A. EPICURE User's Guide.Seattle: Hirosoft International Corp., 1992.

22. Accumulated effective average doses. Bulletin of the National Radiation and Epidemiological Registry, special issue, 1999.

23. Gilbert E.S., Cragle D.L., Wiggs L.D. Updated analysis of combined mortality data for workers at the Hanford Site, Oak Ridge National Laboratory and Rocky Flats Nuclear Weapons Plant. Radiat Res. 1993. V. 136. PP. 408-421.

24. Kendall G.M., Muirhead C.R., MacGibbon B.H. et al. Mortality and occupational exposure to radiation: first analysis of the National Registry for radiation workers. Br. Med. J. 1992. V. 304. PP. 220-225.

25. Muirhead C.R., Goodill A.A., Haylock R.G. et al. Occupational radiation exposure and mortality: second analysis of the National Registry for radiation workers. J. Radiol. Prot. 1999. V. 19. PP. 3-26.

26. Asmore J.P., Krewsky D., Zielinsky J.M. et al. First analyses of mortality and occupational radiation exposure based on National Dose Registry of Canada. Am. J. Epidemiol. 1998. V. 148. PP. 564-574.

27. Carpenter L., Higgins C., Douglas A., Fraser P., Beral V., Smith P. Combined analysis of mortality in the three United Kingdom Nuclear industry workforces, 1946-1988. Radiat. Res. 1994.V. 138. PP. 224-238.

28. Gribbin M.A., Weeks J.L., Howe G.R. Cancer mortality (1956-1985) among male employees of atomic energy of Canada limited with respect to occupational exposure to external low-linear-energy-transfer ionizing radiation. Radiat. Res. 1993. V. 133. PP. 375-380.

29. Ron E., Muirhead C. The carcinogenic effects of ionizing radiation: epidemiological evidence. In: Low doses of ionizing radiation: biological effects and regulatory control. Invited papers and discussion. Proceedings of an International conference, Seville, Spain, 17-21 November 1997.Vienna: International Atomic Energy Agency, 1998. PP. 165-180.

30. Koshurnikova N.A., Bysogolov G.D., Bolotnikova M.G. et al. Mortality among personnel who worked at the Mayak complex in the first years of its operation. Health Phys. 1996. V. 71. PP. 90-93.

31. Ivanov V.K., Gorski A.I., Maksioutov M.A., Tsyb A.F., Souchkevitch G.N. Mortality among the Chernobyl emergency workers: estimation of radiation risks (preliminary analysis). Health Phys. 2001. V. 81, No. 5. PP. 514-521.

32. Ivanov V.K., Tsyb A.F., Rastopchin E.M., Gorsky A.I., Maksyoutov M.A., Vayser V.I., Suspitsin Y.V., Fedorov Y.V. Cancer incidence among nuclear workers in Russia based on data from the Institute of Physics and Power Engineering: a preliminary analysis. Radiat. Res. 2001. V. 155. PP. 801-808.

33. Ivanov V.K., Tsyb A.F., Petrov A.V., Maksioutov M.A., Shilyaeva T.P., Kochergina E.V. Thyroid cancer incidence among liquidators of the Chernobyl accident: absence of dependence of radiation risks on ex-ternal radiation dose. Radiation and Environmental Biophysics. 2002. V. 41, No. 3 (Sep). PP. 195-198.

34. Ivanov V.K., Rastopchin E.M., Gorsky A.I., Ryvkin V.B. Cancer incidence among liquidators of the Chernobyl accident: solid tumors, 1986-1995. Health Physics. 1998. V. 74(3). PP. 309-315.

35. Sources and Effects of Ionizing Radiation. UNSCEAR 2000 Report. Vol. II. Effects.New York: United Nations, 2000. PP. 470-471.

36. International Classification of Diseases, 10th Revision.Geneva: WHO, 1977.

37. Pitkevich V.A., Ivanov V.K., Tsyb A.F. Dosimetric data of the All-Russian Medical and Dosimetric State Registry for emergency workers. Special Issue of Bulletin of the All-Russian Medical and Dosimetric State Registry. Moscow, 1995.

38. Pierce A., Preston D.L. Commentary on: No evidence for increased tumor rates below 200 mSv in the atomic bomb survivors’ data. Radiat. Environ. Biophys. 1997. V. 36, No. 3. PP. 209-210.

39. Griem M.L., Kleinerman R.A., Boice J.D.Jr. et al. Cancer following radiotherapy for peptic ulcer. J. Natl. Cancer Inst.1994.V. 86.P. 842-849.

40. Darby S.C., Doll R., Gill S.K. et al. Long term mortality after a single treatment course with X-rays in people treated for ankylosing spondylitis. Br. J. Cancer. 1987. V. 55. PP. 179-190.

41. Lewis C.A., Smith P.G., Stratton I.M. et al. Estimated radiation doses to different organs among patients treated for ankylosing spondylitis with a single course of X-rays. Br. J. Radiol. 1988. V. 61. PP. 212-220.

42. Shimizu Y., Pierce D.A., Preston D.L., Mabuchi K. Studies of the mortality of atomic bomb survivors. Report 12, Part II. Noncancer mortality: 1950-1990. Radiat. Res. 1999. V. 152, No. 4. PP. 374-389.

43. Kodama K., Fujiwara S., Yamada M. et al. Profiles of non-cancer diseases in atomic bomb survivors. World Health Stat. Q. 1996. V. 49. PP. 7-16.

44. Ivanov V.K., Tsyb A.F., Maksyutov M.A., Pitkevich V.A., Gorsky A.I., Rastopchin Eu.M., Korelo A.M., Chekin S. Yu., Konogorov A.P., Nilova E.V. Radiation epidemiological analysis of the data of the National Chernobyl Registry of Russia: prognostication and facts nine years after the accident. Radiat. Prot. Dosimetry. 1994. V. 64. PP. 121-128.

45. Ivanov V.K., Maksioutov M.A., Chekin S.Yu., Kruglova Z.G., Petrov A.V., Tsyb A.F. Radiation-epidemiological analysis of incidence of non-cancer diseases among the Chernobyl liquidators. Health Phys. 2000. V. 78, No. 5. PP. 495-501.

46. Pitkevitch V.A., Ivanov V.K., Tsyb A.F., Maksyoutov M.A., Matiash V.A., Shchukina N.V. Exposure levels for persons involved in recovery operations after the Chernobyl accident. Statistical analysis based on the data of the Russian National Medical and Dosimetric Registry (RNMDR). Radiat. Environ. Biophys. 1997. V. 36, No. 3. PP. 149-160.

47. Breslow N.E., Day N.E. Statistical Methods in Cancer Research. Vol. I.The Analysis of Case-Control Studies. IARC Scientific Publication No. 32.Lyon: IARC, 1980.

48. Pierce D.A., Shimizu Y., Preston D.L., Vaeth M., Mabuchi K. Studies of the mortality of atomic bomb survivors. Report 12, Part I. Cancer: 1950-1990. Radiation Research. 1996. V. 146. PP. 1-27.

49. Pierce D.A., Mendelsohn M.L. A model for radiation-related cancer suggested by atomic bomb survivor data. Radiat. Res.1999. V. 52, No. 6. PP. 642-654.

50. Mikhalsky A.I., Petrovsky A.M., Yashin A.I. Theory of estimation of heterogeneous populations. Science Publ., 1989.

51. Mikhalsky A.I. Methods for analyzing heterogeneous structures and populations. V.A. Trapeznikov Institute for Management Problems of RAS, 2002.

52. Cardis E., Vrijheid M., Blettner M., Gilbert E., Hakama M., Hill C., Howe G., Kaldor J., Muirhead C.R., Schubauer-Berigan M., Yoshimura T., Bermann F., Cowper G., Fix J., Hacker C., Heinmiller B., Marshall M., Thierry-Chef I., Utterback D., Ahn Y.-O., Amoros E., Ashmore P., Auvinen A., Bae J.-M., Bernar Solano J., Biau A., Combalot E., Deboodt P., Diez Sacristan A., Eklof M., Engels H., Engholm G., Gulis G., Habib R., Holan K., Hyvonen H., Kerekes A., Kurtinaitis J., Malker H., Martuzzi M., Mastauskas A., Monnet A., Moser M., Pearce M.S., Richardson D.B., Rodriguez-Artalejo F., Rogel A., Tardy H., Telle-Lamberton M., Turai I., Usel M., Veress K. Risk of cancer after low doses of ionising radiationretrospective cohort study in 15 countries. BMJ. 2005. V. 89. PP. 1-7.

53. Wakeford R. Cancer risk among nuclear workers. J. Radiol. Prot. 2005. V. 25. PP. 225-228.

54. Ivanov V.K., Tsyb A.F., Agapov A.M., Panfilov A.P., Kaydalov O.V., Gorsky A.I., Maksyutov M.A., Chekin S.Yu., Godko A .M., Suspitsin Yu.V., Weiser V.I., Kozlov E.P., Epikhin A.I. The concept of optimizing the radiation protection system in the nuclear industry: managing individual carcinogenic risks and providing targeted medical care. Radiation and risk, special issue, 2004.

55. Cox D.R. Partial likelihood. Biometrika.1975. V. 62. PP. 269-276.

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