Long-term cytogenetic effects of chronic occupational irradiation

"Radiation and Risk", 2000, Special Issue, pp.105-108
Selected articles from the journal "Bulletin of Radiation Medicine", 1993, No. 1, pp. 85-90


Okladnikova N.D., Burak L.E.


Status of chromosomal apparatus of lymphocytes of peripheral blood was estimated in 134 patients with chronic radiation sickness caused by external gamma-radiation in 30-35 years after establishing the diagnosis. Increased rate of aberrant cells with structural chromosomal aberrations compared to the baseline was found in the majority of the examined people. A half of chromosomal aberrations were rearrangements of stable type. 20-year dynamic examination showed long-term retaining of chromosomal aberrations with gradual increase in a fraction of stable aberrations in their structure.

Key words
The state of the chromosome apparatus of peripheral blood lymphocytes, chronic radiation sickness (CHL), chromosomal abnormalities, γ-irradiation, dose dependence, frequency of aberrant cells, chromosomal aberrations.


1. Malakhov V.S. The level of aberrant lymphocytes in the blood of rats and the life span of animals after incorporation of radionuclides. Radiobiology. 1987. Vol. 27, No. 5. PP. 691-693.

2. Maxinova K.N. Kinetics of cellular populations of the main sections of the hematopoiesis system during long-term external irradiation: Diss. Doct. med. Science Institute of Biophysics of the Ministry of Health of the USSR. Inv. No. 1646, 1985. 471 p.

3. Okladnikova N.D. The state of the chromosomal apparatus of hemopoietic cells in individuals exposed to prolonged external irradiation and tritium exposure: Diss. Cand. med. sciences. M., 1972.

4. Okladnikova N.D. PHA-stimulating effect and chromosomal aberrations in the culture of leukocytes of peripheral blood of patients with lung cancer etiology. Bul. radi. honey. 1987. No. 2. PP. 32-38.

5. Streltsova V.N. On some questions of the pathogenesis of the long-term effects of radiation on animals. Proc. of the All-Union Conf. "Remote impact and risk assessment of radiation exposure". M., 1978. PP. 38-39.

6. Proliferation, differentiation and possible radiation-induced chromosome anormalities in ciculating ho- mopoietic-stem cells. T.Amonorosi, T. Honda et. al. Technical report, RERP, 1986. P. 15.

7. Changing P., Shuging G., Yuau Y. Chromosomal analysis and comparisation between normal and malignant transformed C3H / 10T 1/2 cells . Clin. J. Radiol. Med. Protect. 1986. No. 6. PP. 313-315.

8. Chromosome prepatation of leukocyted from human peropheral blood / P.S. Moorhead et. al. . Exp. Cell. Res. 1960. No. 20. P. 613.

Full-text article (in Russian)