Chromosomal aberrations in lymphocytes of peripheral blood of patients with chronic radiation sickness in 25-30 years after termination of contact with radiation factor

"Radiation and Risk", 2000, Special Issue, pp.101-104
Selected articles from the journal "Bulletin of Radiation Medicine", 1985, No. 1, pp. 102-106


Okladnikova N.D.


Cytogenetic study of 273 patients with chronic radiation sickness caused mainly by total external radiation in 25-30 years after termination of occupational contact with radiation factor was carried out. Structural damages of chromosomal type were detected in 81.7% of cases, rate of the damages considerably exceeded the baseline level of spontaneous aberrations. At the level of integrated doses from gamma-radiation of 100-600 rad (1.0-6.0 Gy) relationship between dose and the rate of chromosomal aberrations was not found. Chromosomal changes for 10-12 years of follow-up were dynamically estimated in 97 individuals. Increase in the number of chromosomal aberrations (mainly of stable type) was detected in patients with chronic radiation sickness who were “carriers” of 239Pu.

Key words
Chronic radiation sickness (CHL), external irradiation, chromosomal type disorders, γ-radiation, dose dependence, frequency of chromosomal aberations, 239Pu.


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