Chromosomal aberrations in lymphocytes of peripheral blood of patients with chronic radiation sickness in 25-30 years after termination of contact with radiation factor

"Radiation and Risk", 2000, Special Issue, pp.101-104
Selected articles from the journal "Bulletin of Radiation Medicine", 1985, No. 1, pp. 102-106

Authors

Okladnikova N.D.

Abstract

Cytogenetic study of 273 patients with chronic radiation sickness caused mainly by total external radiation in 25-30 years after termination of occupational contact with radiation factor was carried out. Structural damages of chromosomal type were detected in 81.7% of cases, rate of the damages considerably exceeded the baseline level of spontaneous aberrations. At the level of integrated doses from gamma-radiation of 100-600 rad (1.0-6.0 Gy) relationship between dose and the rate of chromosomal aberrations was not found. Chromosomal changes for 10-12 years of follow-up were dynamically estimated in 97 individuals. Increase in the number of chromosomal aberrations (mainly of stable type) was detected in patients with chronic radiation sickness who were “carriers” of ²³⁹Pu.

Key words
Chronic radiation sickness (CHL), external irradiation, chromosomal type disorders, γ-radiation, dose dependence, frequency of chromosomal aberations, ²³⁹Pu.

References

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