The radiation damage of thyroid gland may be the reason of increase of frequency Non-Hodgkin’s lymphoma and others hematological diseases

"Radiation and Risk" 1997. Vol. 10, pp.125-128

Сведения об авторах

Vinogradova Yu.E.1), Shinkarkina A.P.2, Poverenny А.М.2
1Botkin’s Clinical Hospital, Moscow
2Medical Radiological Research Center of RAMS, Obninsk

Abstract

Distribution of autoimmune thyroidites in the patients with diseases of blood system is investigated. Antimicrosomal antibodies served as an indicator of autoimmune thyroidites. Autoimmune thyroidites was found more often in patients with various hematological diseases than in the control group. A hypothesis is advanced that the increase in the frequency of some hematological diseases in the residents affected by the Chernobyl accident can be attributed not only to the influence of the radiation on blood system, but also to the damage of thyroid glands.

Key words
Autoimmune thyroiditis, antibodies to the microsomal fraction, thyroid gland, signs of autoimmune thyroiditis, hematological diseases, hematopoietic system, Chernobyl accident.

References

1. Vinogradova Yu.E., Vinogradov D.A, Attorney A.M., Tsyb A.F. Autoimmune thyroiditis in patients with certain hematological diseases. Therapeutic archive. 1994. No.7. PP. 65-68.

2. Kassirsky I.A., Alekseev G.A. Clinical hematology. M., 1970.

3. Okeanov A.V., Demidchik E.P., Ankudovich M.A. The incidence of thyroid cancer in the Republic of Belarus. Radiation and risk. 1995. Vol. 6 PP. 236-239.

4. Attorney A.M., Shinkarkina A.P., Podgorodnichenko V.K. et al. Immunological methods in epidemiological monitoring of the population exposed to radioactive iodine as a result of the Chernobyl accident. Radiation biology. Radioecology. 1993. Vol. 33, Vol. 1 (4). PP. 479-483.

5. Semenkevich K. Therapeutic Handbook of the University of Washington. Ed. M. Woodley, A. Walsh. M .: Praktika, 1995. p. 550.

6. Shinkarkina A.P., Podgorodnichenko V.K., Attorney A.M. Antibodies to the microsomal antigen of the thyroid gland in children and adolescents exposed to radiation as a result of the Chernobyl accident. Radiation and Risk. 1994. Vol. 4. PP. 125-129.

7. Banga J., Barnett P., Gregor M. et al. Immunological and molecular characteristics of the thyroid peroxidase autoantigen. Autoimmunity. 1991. Vol. 8. PP. 335-343.

8. De Groot L., Palogan E. Serum antigens and antibodies in the diagnosis of thyroid cancer. J. Amer. Med. Ass. 1973. Vol. 255. PP. 487-491. Vol. 78. PP. 1329-1334.

9. Hyjek E., Jsaacson P. Primary B-cell lymphoma of the thyroid and its relationship to Hashimoto’s thyroiditis. Hum. Pathol. 1988. V. 19. P. 1315-1326.

10. Jansson R., Thompson P., Clark F., McLachlan S. Association between thyroid microsomal antibodies of subclass IgG1 and hypothyroidism in autoimmune post- partum thyroiditis. Clin. Exp. Immunol. 1986. Vol. 63. PP. 80-86.

11. Mascovitz C., Dutcher J., Wiernik S. Association of thyroid disease with acute leukemia. Amer. J. Hematol. 1992. Vol. 39. PP. 102-107.

12. Poverenny A., Shinkarkina A., Podgorodnichenko V.K. et al. Signs of autoimmune thyroiditis in children and juveniles affected by the Chernobyl accident. Radiat. Protect. Dosimetry. 1995. V. 62, N 1/2. P. 75-76.

13. Refetaff S., Harrison J., Karanfilski B. et al. Continuing occurrence of thyroid carcinoma after irradiation to the neck in infancy and childhood. N. Engl. J. Med. 1975. Vol. 292. PP. 171-175.

14. Santana V., Rose N. Neoplastic lymphoproliferation in autoimmune disease. Clin. Immunol. Immunopathol. 1992. Vol. 63. PP. 205-213.

15. Sundick R., Bagchi N., Brown Th. The role of iodine in thyroid autoimmunity. Autoimmunity. 1992. Vol. 13, No. 1. PP. 61-68.

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