Issues
Radiation therapy in the palliative treatment of advanced lung cancer
Authors
Ivanova I.N. – Physician-Radiologist, C. Sc., Med., Medical Radiological Research Center of the Russian Ministry of Health, Obninsk. Contacts: 4 Korolyov str., Obninsk, Kaluga region, Russia, 249036. Tel.: +79109144245; e-mail:
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Gulidov I.A. – Head of Dep., MD, Prof., Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Mardynsky Y.S. – Head of Dep., Corresponding Member of RAMS, Prof., Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Zolotkov A.G. – Main Researcher, MD, Prof., Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Gogolin D.V. – Physician-Radiologist, Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Ragulin Y.A. – Head of Dep., C. Sc., Med., Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Kursova L.V. – Lead. Researcher, C. Sc., Med., Medical Radiological Research Center of the Russian Ministry of Health, Obninsk.
Abstract
The purpose of this study was to evaluate efficiency of different unconventional radiation therapy schedules for advanced small-cell lung cancer (SCLC). The material for the study is based on data on the treatment of 108 patients with a verified diagnosis of SCLC. For the study the patients were subdivided into three groups in relation to the mode of fractionation of radiation dose. As a result of the study we managed to assess the tolerability of different fractionation schemes, ate outcome of the treatment, as well as to bring to light the advantages of accelerated hyperfractionated radiation therapy.
Key words
Small cell lung cancer, accelerated hyperfractionation, chemoradiation therapy, early and late complications.
References
1. Bychkov M.B. Melkokletochnyi rak legkogo: chto izmenilos' za poslednie 30 let? Sovremennaia onkologiia, 2007, vol. 9, no. 1, pp. 34-36.
2. Val'kov M.Iu., Zolotkov A.G., Mardynskii Iu.S. i dr. Uskorennye skhemy fraktsionirovaniia v luchevom lechenii neoperabel'nogo nemelkokletochnogo raka legkogo. Voprosy onkologii, 2003, vol. 49, no. 5, pp. 647-651.
3. Zolotkov A.G., Mardynskii Iu.S., Gulidov I.A. i dr. Povyshenie effektivnosti luchevoi terapii raka legkogo: klinicheskie i ekonomicheskie problemy. Klinicheskaia radiologiia, 2008, no. 3, pp. 16-20.
4. Zolotkov A.G., Mardynskii Iu.S., Gulidov I.A. Luchevaia terapiia opukholei legkikh Terapevticheskaia radiologiia: rukovodstvo dlia vrachei /Pod red. A.F. Tsyba i Iu.S. Mardynskogo. Moscow, 2010, pp. 170-173.
5. Sostoianie onkologicheskoi pomoshchi naseleniiu Rossii v 2010 godu /Pod red. V.I. Chissova, V.V. Starinskogo, G.V.Petrovoi. Moscow, 2011.
6. Stavitskii R.V., Pan'shin G.A. Perifericheskii rak legkogo: kolichestvennaia otsenka effektivnosti radikal'nogo khimioluchevogo lecheniia. Moscow, 2008, pp. 95-103.
7. American society of clinical oncology. (ASCO) 43rd Annual Meeting ASCO 2007. June 1-5. Chicago, Illinois. 2007.
8. Gaspar L.E. Limited small cell lung cancer (stage 1-3): observation from the NCL. ASCO. 2004. Abs. 7042.
9. Quioix E. Is there are improvement of survival in SCLC patients? II International conference «New perspectives in the treatment of SCLC», Lausanne, 2002, pp. 129-130.
10. Shepherd F.A., Crowley J., van Houtte P. et al. The International Association for the Study of Lung Cancer Staging Project: proposals regarding the clinical staging of small sell lung cancer in the forthcoming (seventh) edition of the Tumor, Node, Metastasis Classification for Lung Cancer. J. Thoracic. Oncol., 2007, vol. 3, pp. 1067-1077.
11. Thatcher N. Some treatment concepts in SCLC. VII Eur. conf. «Perspectives in lung cancer». Athens., 2006, pp. 67-73.
12. Turrisi A.T., III, Kim K., Blum R. et al. Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide. The New England Journal of Medicine, 2011, vol. 340, no. 4, pp. 265-271.